Chromosomal Changes Induced in Mouse Bone Marrow Cells Following Six Weeks Inhalation of Cyclohexanol

Abstract

The effects of low doses of cyclohexanol exposure were studied in mouse bone marrow cells including chromosome aberrations (CA), micronucleus (MN) and sister chromatid exchanges (SCE) as biomarkers. Capillaries with a tested agent that was evaporated continuously were placed in an experimental chamber for six weeks. No clastogenic and/or aneugenic effect of CA and MN induction was observed. A significant elevation of induced damage was achieved in the SCE study (p < 0.001) that has confirmed the early exposure of cyclohexanol to mice.

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Acknowledgement

The Ministry of Education and Science of the Slovak Republic (Grant No. 1/4322/07 and 1/4394/07) have supported this work.

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Correspondence to Katarína Šiviková.

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Šiviková, K., Dianovský, J., Piešová, E. et al. Chromosomal Changes Induced in Mouse Bone Marrow Cells Following Six Weeks Inhalation of Cyclohexanol. BIOLOGIA FUTURA 58, 389–396 (2007). https://doi.org/10.1556/ABiol.58.2007.4.6

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Keywords

  • Cyclohexanol
  • mice bone marrow
  • chromosome aberrations
  • sister chromatid exchanges
  • micronuclei