Chromosomal Changes Induced in Mouse Bone Marrow Cells Following Six Weeks Inhalation of Cyclohexanol
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The effects of low doses of cyclohexanol exposure were studied in mouse bone marrow cells including chromosome aberrations (CA), micronucleus (MN) and sister chromatid exchanges (SCE) as biomarkers. Capillaries with a tested agent that was evaporated continuously were placed in an experimental chamber for six weeks. No clastogenic and/or aneugenic effect of CA and MN induction was observed. A significant elevation of induced damage was achieved in the SCE study (p < 0.001) that has confirmed the early exposure of cyclohexanol to mice.
KeywordsCyclohexanol mice bone marrow chromosome aberrations sister chromatid exchanges micronuclei
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The Ministry of Education and Science of the Slovak Republic (Grant No. 1/4322/07 and 1/4394/07) have supported this work.
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