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Acta Biologica Hungarica

, Volume 58, Issue 4, pp 389–396 | Cite as

Chromosomal Changes Induced in Mouse Bone Marrow Cells Following Six Weeks Inhalation of Cyclohexanol

  • Katarína ŠivikováEmail author
  • J. Dianovský
  • Elena Piešová
  • Beáta Holečková
Article
  • 1 Downloads

Abstract

The effects of low doses of cyclohexanol exposure were studied in mouse bone marrow cells including chromosome aberrations (CA), micronucleus (MN) and sister chromatid exchanges (SCE) as biomarkers. Capillaries with a tested agent that was evaporated continuously were placed in an experimental chamber for six weeks. No clastogenic and/or aneugenic effect of CA and MN induction was observed. A significant elevation of induced damage was achieved in the SCE study (p < 0.001) that has confirmed the early exposure of cyclohexanol to mice.

Keywords

Cyclohexanol mice bone marrow chromosome aberrations sister chromatid exchanges micronuclei 

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Notes

Acknowledgement

The Ministry of Education and Science of the Slovak Republic (Grant No. 1/4322/07 and 1/4394/07) have supported this work.

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Copyright information

© Akadémiai Kiadó, Budapest 2007

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • Katarína Šiviková
    • 1
    Email author
  • J. Dianovský
    • 1
  • Elena Piešová
    • 1
  • Beáta Holečková
    • 1
  1. 1.Institute of GeneticsUniversity of Veterinary MedicineKošiceSlovakia

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