Acta Biologica Hungarica

, Volume 57, Issue 2, pp 201–209 | Cite as

A Study on the Antioxidant Activities of Some New Benzazole Derivatives

  • O. Temiz-Arpaci
  • T. Coban
  • B. Tekiner-Gulbas
  • B. Can-Eke
  • I. YildizEmail author
  • E. Aki-Sener
  • I. Yalcin
  • M. Iscan


The in vitro antioxidant properties of some new benzazole derivatives (1–10) such as benzoxazoles, ben-zimidazoles, and benzothiazoles were determined by their effects on the rat liver microsomal NADPH-dependent lipid peroxidation (LP) level, the scavenging of superoxide anion and the stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). Compounds 1, 2, 4 and 6, showed potent scavenging effect on super-oxide radical at 10−3 M. Compound 8, 5-nitro-2-(phenoxymethyl)benzimidazole, strongly inhibited lipid peroxidation at 10−3 M concentration.


Antioxidant activity benzazole derivatives superoxide dismutase lipid peroxidation DPPH 


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© Akadémiai Kiadó, Budapest 2006

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • O. Temiz-Arpaci
    • 1
  • T. Coban
    • 2
  • B. Tekiner-Gulbas
    • 1
  • B. Can-Eke
    • 2
  • I. Yildiz
    • 1
    Email author
  • E. Aki-Sener
    • 1
  • I. Yalcin
    • 1
  • M. Iscan
    • 2
  1. 1.Department of Pharmaceutical Chemistry, Faculty of PharmacyAnkara UniversityAnkaraTurkey
  2. 2.Department of Pharmaceutical Toxicology, Faculty of PharmacyAnkara UniversityAnkaraTurkey

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