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Acta Biologica Hungarica

, Volume 56, Issue 3–4, pp 247–259 | Cite as

Influence of Subcutaneous Injection of Essential Fatty Acids on the Stress-Induced Modifications of Rat Platelet Aggregation and Membrane Lipid Composition

  • Sophie Ermidou-PolletEmail author
  • H. Nounopoulos
  • N. Sdougas
  • M. Szilágyi
  • S. Pollet
Article

Abstract

Membrane lipids play an important role in the function of blood platelets but the mechanisms by which the lipid composition of the platelet membrane is adjusted remain unclear. It has been shown that stress and poly-unsaturated fatty acids modified the lipid composition of blood plasma and platelet lipids, but very little is known about the effect of stress and fatty acids on membrane platelet lipid composition. The purpose of the present investigation was to study the influence of the essential fatty acids: linoleic, linolenic and arachidonic acids on the composition of the platelet membrane lipids of rats assigned to heat and restraint stress. It was shown that injections of polyunsaturated fatty acids decrease or suppress the stress-induced increase in platelet aggregation, suppress the stress-induced modification of the composition of the platelet membrane lipids and modify the fatty acid composition of the platelet membrane phospholipids.

Keywords

Stress essential fatty acids platelet lipids 

Abbreviations

PE

phosphatidyl-ethanolamine

PC

phosphatidyl-choline

PS

phosphatidyl-serine

PI

phosphatidyl-inositol

Sph

sphingomyelin

AP

phosphatidic acid

Cer

cerebrosides

Sulf

sulfatides

GG

gangliosides

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© Akadémiai Kiadó, Budapest 2005

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • Sophie Ermidou-Pollet
    • 1
    Email author
  • H. Nounopoulos
    • 1
  • N. Sdougas
    • 1
  • M. Szilágyi
    • 2
  • S. Pollet
    • 1
  1. 1.Department of Biological Chemistry, Medical SchoolUniversity of AthensGreece
  2. 2.Research Institute for Animal Breeding and NutritionHerceghalomHungary

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