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Acta Biologica Hungarica

, Volume 56, Issue 3–4, pp 225–232 | Cite as

Short-Term Thyroxine Administration Leads to Lipid Peroxidation in Renal and Testicular Tissues of Rats with Hypothyroidism

  • R. MogulkocEmail author
  • A. K. Baltaci
  • E. Oztekin
  • A. Ozturk
  • A. Sivrikaya
Article

Abstract

Thyroid dysfunction brings about pathological changes in different organs of the body. The aim of the present study was to examine how experimental hypothyroidism and additional short-term high-dose thyroxine administration (one-week) affected lipid peroxidation in renal and testicular tissues of rats. The study was carried out on 30 male Spraque-Dawley rats. The experimental animals were divided into 3 groups as control, hypothyroidism and hypothyroidism + thyroxine administration. Both malondialdehyde (MDA) and glutathione (GSH) levels were lower in renal and testicular tissues of the hypothyroidism group than the control and hypothyroidism + thyroxine administration groups and the levels in hypothyroidism + thyroxine administration group were higher than those in the control and hypothyroidism groups (p < 0.001). Results of the study demonstrate that hypothyroidism reduced oxidant stress in kidney and testis tissues, but short-term, high-dose thyroxine administration in addition to hypothyroidism increased oxidant stress in the same tissues of rats.

Keywords

Hypothyroidism thyroxine administration oxidant stress rat 

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© Akadémiai Kiadó, Budapest 2005

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • R. Mogulkoc
    • 1
    Email author
  • A. K. Baltaci
    • 1
  • E. Oztekin
    • 2
  • A. Ozturk
    • 3
  • A. Sivrikaya
    • 2
  1. 1.Department of PhysiologyMeram Medical School, Selcuk UniversityKonyaTurkey
  2. 2.Department of BiochemistryMeram Medical School, Selcuk UniversityKonyaTurkey
  3. 3.Department of UrologyMeram Medical School, Selcuk UniversityKonyaTurkey

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