Thyroid dysfunction brings about pathological changes in different organs of the body. The aim of the present study was to examine how experimental hypothyroidism and additional short-term high-dose thyroxine administration (one-week) affected lipid peroxidation in renal and testicular tissues of rats. The study was carried out on 30 male Spraque-Dawley rats. The experimental animals were divided into 3 groups as control, hypothyroidism and hypothyroidism + thyroxine administration. Both malondialdehyde (MDA) and glutathione (GSH) levels were lower in renal and testicular tissues of the hypothyroidism group than the control and hypothyroidism + thyroxine administration groups and the levels in hypothyroidism + thyroxine administration group were higher than those in the control and hypothyroidism groups (p < 0.001). Results of the study demonstrate that hypothyroidism reduced oxidant stress in kidney and testis tissues, but short-term, high-dose thyroxine administration in addition to hypothyroidism increased oxidant stress in the same tissues of rats.
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Mogulkoc, R., Baltaci, A.K., Oztekin, E. et al. Short-Term Thyroxine Administration Leads to Lipid Peroxidation in Renal and Testicular Tissues of Rats with Hypothyroidism. BIOLOGIA FUTURA 56, 225–232 (2005). https://doi.org/10.1556/ABiol.56.2005.3-4.6
- thyroxine administration
- oxidant stress