Acta Biologica Hungarica

, Volume 56, Issue 3–4, pp 225–232 | Cite as

Short-Term Thyroxine Administration Leads to Lipid Peroxidation in Renal and Testicular Tissues of Rats with Hypothyroidism

  • R. MogulkocEmail author
  • A. K. Baltaci
  • E. Oztekin
  • A. Ozturk
  • A. Sivrikaya


Thyroid dysfunction brings about pathological changes in different organs of the body. The aim of the present study was to examine how experimental hypothyroidism and additional short-term high-dose thyroxine administration (one-week) affected lipid peroxidation in renal and testicular tissues of rats. The study was carried out on 30 male Spraque-Dawley rats. The experimental animals were divided into 3 groups as control, hypothyroidism and hypothyroidism + thyroxine administration. Both malondialdehyde (MDA) and glutathione (GSH) levels were lower in renal and testicular tissues of the hypothyroidism group than the control and hypothyroidism + thyroxine administration groups and the levels in hypothyroidism + thyroxine administration group were higher than those in the control and hypothyroidism groups (p < 0.001). Results of the study demonstrate that hypothyroidism reduced oxidant stress in kidney and testis tissues, but short-term, high-dose thyroxine administration in addition to hypothyroidism increased oxidant stress in the same tissues of rats.


Hypothyroidism thyroxine administration oxidant stress rat 


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© Akadémiai Kiadó, Budapest 2005

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • R. Mogulkoc
    • 1
    Email author
  • A. K. Baltaci
    • 1
  • E. Oztekin
    • 2
  • A. Ozturk
    • 3
  • A. Sivrikaya
    • 2
  1. 1.Department of PhysiologyMeram Medical School, Selcuk UniversityKonyaTurkey
  2. 2.Department of BiochemistryMeram Medical School, Selcuk UniversityKonyaTurkey
  3. 3.Department of UrologyMeram Medical School, Selcuk UniversityKonyaTurkey

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