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Acta Biologica Hungarica

, Volume 56, Issue 1–2, pp 21–34 | Cite as

Antinociceptive Action of Aqueous Extract of The Leaves of Ixora Coccinea

  • W. D. RatnasooriyaEmail author
  • S. A. Deraniyagala
  • S. D. N. K. Bathige
  • C. L. Goonasekara
  • J. R. A. C. Jayakody
Article

Abstract

The aim of this study was to examine the antinociceptive potential of leaves of Ixora coccinea (family: Rubeaceae). One of four doses (500, 750, 1000 or 1500 mg/kg, n=8/dose) of aqueous leaf extract (ALE) or 1 ml of distilled water was orally administered to male rats and antinociceptive activity was ascertained using three models of nociception (tail flick, hot plate and formalin tests). The results showed that ALE possesses considerable antinociceptive activity (when evaluated in hot plate and formalin test but not in tail flick test). The antinociceptive activity of the ALE had a rapid onset (within 1 h) and a fairly long duration of action (up to 5 h) with a peak effect at 3 h. Further, the antinociceptive activity was dose-dependent and was not associated with harmful side-effects or toxicity even following subchronic administration. The antinociceptive action was mediated centrally at the supraspinal level mainly via dopaminergic mechanism. In addition, it is likely that antioxidant activity of the ALE could have played an auxiliary role in inducing antinociception. Dopaminergic and antioxidative activities of ALE could arise, respectively, from its quaternary base alkaloid and flavonoid constituents.

Keywords

Ixora coccinea antinociception pain toxicology 

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© Akadémiai Kiadó, Budapest 2005

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • W. D. Ratnasooriya
    • 1
    Email author
  • S. A. Deraniyagala
    • 2
  • S. D. N. K. Bathige
    • 2
  • C. L. Goonasekara
    • 2
  • J. R. A. C. Jayakody
    • 1
  1. 1.Department of ZoologyUniversity of ColomboColombo-03Sri Lanka
  2. 2.Department of ChemistryUniversity of ColomboColombo-03Sri Lanka

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