Cell Density-Correlated Induction of Pyruvate Decarboxylase Under Aerobic Conditions in the Yeast Pichia Stipitis
During the aerobic batch cultivation of P. stipitis CBS 5776 with glucose, pyruvate decarboxylase was activated in a cell number-correlated manner. Activation started when a cell number between 7×107 and 1×108 cells ml−1 was reached and the enzyme activity increased during further cultivation. This induction might have been triggered either by an unknown quorum sensing system or by a shortage of cytoplasmic acetyl-CoA.
KeywordsPyruvate decarboxylase Pichia stipitis aerobic activity
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