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Acta Biologica Hungarica

, Volume 68, Issue 4, pp 443–452 | Cite as

In vivo Screening of Diterpene Alkaloids using Bdelloid Rotifer Assays

  • Tivadar Kiss
  • Lilla Mácsai
  • Dezső CsuporEmail author
  • Zsolt László DatkiEmail author
Article
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Abstract

The group of diterpene alkaloids contains numerous compounds with complex chemistry and diverse pharmacological activities. Beside toxicity, these compounds possess activity on the cardiovascular system, tumor cell lines and nervous system. The pharmacological properties have been described using in vitro and in vivo techniques; however, the bioactivities of many compounds have not thoroughly been studied. Here we report on the in vivo evaluation of ten diterpene alkaloids using bdelloid rotifer assays. Napelline exerted toxic effects on rotifers, while wide tolerance range was observed for other investigated compounds. Weak toxicity of songorine is supported by our experiment. Toxicological data for senbusine A, senbusine C, septentrioidine and hetisinone are reported for the first time.

Keywords

Diterpenoid alkaloids toxicity Aconitum rotifers Philodina acuticornis odiosa 
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© Akadémiai Kiadó, Budapest 2017

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  1. 1.Faculty of Pharmacy, Department of PharmacognosyUniversity of SzegedSzegedHungary
  2. 2.Interdisciplinary Centre for Natural ProductsUniversity of SzegedSzegedHungary
  3. 3.Faculty of Medicine, Department of PsychiatryUniversity of SzegedSzegedHungary

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