Acta Biologica Hungarica

, Volume 68, Issue 2, pp 196–207 | Cite as

Chemical Composition and Antifungal Activity of Hedera Helix Leaf Ethanolic Extract

  • Oana Roşca-CasianEmail author
  • Cristina MirceaEmail author
  • Laurian Vlase
  • Ana-Maria Gheldiu
  • Delia Tania Teuca
  • Marcel Pârvu


The 50% ethanol extract obtained from Hedera helix leaves was investigated regarding the presence and quantity of polyphenols, sterols and in vitro antifungal activity against phytopathogenic fungi. The chemical analysis revealed the presence of rutin, quercetin and kaempferol in the non-hydrolysed sample and quercetin and kaempferol in the hydrolysed sample and stigmasterol in the ivy leaf extract (nonhydrolysed sample). The antifungal activity against phytopathogenic fungi (Aspergillus niger, Botrytis cinerea, B. tulipae, Fusarium oxysporum f. sp. tulipae, Penicillium gladioli, and Sclerotinia sclerotiorum) was assessed using an agar dilution assay. The results are expressed as the minimum inhibitory concentration (MIC = 10–14%) and were compared to a synthetic antifungal drug–fluconazole (MIC = 8–30%). This report presents the first screening of the antifungal activity of the ivy leaf extract on these plant pathogenic fungi species, aiming to use the ivy leaf extract for controlling different diseases of vegetables and ornamental plants, in addition to human disorders.


Antifungal Hedera helix phytopathogenic fungi polyphenols sterols 


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© Akadémiai Kiadó, Budapest 2017

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Authors and Affiliations

  • Oana Roşca-Casian
    • 1
    Email author
  • Cristina Mircea
    • 2
    Email author
  • Laurian Vlase
    • 3
  • Ana-Maria Gheldiu
    • 3
  • Delia Tania Teuca
    • 2
  • Marcel Pârvu
    • 2
  1. 1.“A. Borza” Botanical Garden“Babeş-Bolyai” UniversityCluj-NapocaRomania
  2. 2.Department of Biology, Faculty of Biology and Geology“Babeş-Bolyai” UniversityCluj-NapocaRomania
  3. 3.Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy“Iuliu Haţieganu” University of Medicine and PharmacyCluj-NapocaRomania

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