Acta Biologica Hungarica

, Volume 68, Issue 1, pp 14–21 | Cite as

Diurnal Variation of the Melanin-Concentrating Hormone Level in the Hypothalamus

  • Balázs Gerics
  • Ferenc Szalay
  • Péter Sótonyi
  • Veronika JancsikEmail author
Open Access


Melanin-concentrating hormone (MCH), the neuropeptide produced mainly in the hypothalamus, plays an operative role in regulating food intake and the sleep/wake cycle. Considering that these physiological functions pursue diurnal variations, we checked whether the total hypothalamic MCH level depends on the time of the day. The aggregated MCH peptide content of the whole MCH neuron population was significantly higher at the end of the sleeping period (lights on), than at the end of the active period (lights off). This result, together with earlier observations, indicates that in contrast to the MCH gene expression, the level of MCH peptide is object of circadian variation in the hypothalamus.


Neuropeptide circadian rhythm energy homeostasis sleep 


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© Akadémiai Kiadó, Budapest 2017

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • Balázs Gerics
    • 1
  • Ferenc Szalay
    • 1
  • Péter Sótonyi
    • 1
  • Veronika Jancsik
    • 1
    Email author
  1. 1.Department of Anatomy and HistologyUniversity of Veterinary MedicineBudapestHungary

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