Acta Biologica Hungarica

, Volume 66, Issue 4, pp 464–467 | Cite as

First Phytochemical Investigation of Secondary Metabolites of Euphorbia Davidii Subils. And Antiproliferative Activity of its Extracts

  • Dóra RédeiEmail author
  • Norbert Kúsz
  • Máté Szabó
  • Gyula Pinke
  • István Zupkó
  • Judit Hohmann
Short Communication


The present work is the first phytochemical investigation of Euphorbia davidii Subils. After multistep separation process, three flavonoid glycosides were obtained from the ethyl acetate soluble fraction of the methanol extract of the whole plant. The structures of the isolated compounds were determined as kaemp-ferol 3-O-rhamnoside, myricetin 3-O-rhamnoside, and quercetin 3-O-rhamnoside. Aqueous and organic extracts of the plant were screened in vitro for antiproliferative activity against HeLa (cervix epithelial adenocarcinoma), A431 (skin epidermoid carcinoma), A2780 (ovarian carcinoma) and MCF7 (breast epithelial adenocarcinoma) cells, using the MTT assay. n-Hexane and chloroform extracts demonstrated moderately dose-dependent cell growth inhibitory activity against all four cell lines.


Euphorbia davidii flavonoid glycoside antiproliferative activity 


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© Akadémiai Kiadó, Budapest 2015

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • Dóra Rédei
    • 1
    Email author
  • Norbert Kúsz
    • 1
  • Máté Szabó
    • 1
  • Gyula Pinke
    • 2
  • István Zupkó
    • 3
  • Judit Hohmann
    • 1
  1. 1.Department of PharmacognosyUniversity of SzegedSzegedHungary
  2. 2.Department of Botany, Faculty of Agricultural and Food SciencesUniversity of West HungaryMosonmagyaróvárHungary
  3. 3.Department of Pharmacodynamics and BiopharmacyUniversity of SzegedSzegedHungary

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