Acta Biologica Hungarica

, Volume 66, Issue 2, pp 246–248 | Cite as

Benzene Derivatives Produced by Fusarium Graminearum

  • Khayalethu NtusheloEmail author
  • Itumeleng Setshedi
Short Communication


Using NMR spectroscopy benzene derivatives were detected in mycelia of Fusarium graminearum, a pathogen of wheat and maize. In previous studies F. graminearum was found to cause cancer to humans and benzene derivatives were detected in breath of cancer sufferers. Surprisingly, no study found benzene derivatives to be the cancerous agents in F. graminearum. In this study we detected benzene derivatives in F. graminearum and propose to study their role as cancer agents.


Fusarium graminearum benzene derivatives nuclear magnetic resonance 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    ACD/Structure Elucidator, version 12.01. Advanced Chemistry Development, Inc., Toronto, O., Canada., 2014.
  2. 2.
    Bucci, T., Hansen, D. K., Laborde, J. B. (1996) Leucoencephalomacia and hemorrhage in the brain of rabbits gavaged with mycotoxin fumonisin B1. Nat. Toxins 4, 51–52.CrossRefGoogle Scholar
  3. 3.
    Desjardins, A. E., Hohn, T. M. (1997) Mycotoxins in plant pathogenesis. Mol. Plant Microbe In. 10, 147–152.CrossRefGoogle Scholar
  4. 4.
    Desjardins, A. E., Hohn, T. M., McCormick, S. P. (1993) Trichothecene biosynthesis in Fusarium species: chemistry, genetics, and significance. Microbiol. Mol. Biol. Rev. 57, 595–604.Google Scholar
  5. 5.
    Goswami, R. S., Kistler, H. C. (2004) Heading for disaster: Fusarium graminearum on cereal crops. Mol. Plant Pathol. 5, 515–525.CrossRefGoogle Scholar
  6. 6.
    Fandohan, P., Hell, K., Marasas, W. F. O., Winfgield, M. J. (2003) Infection of maize by Fusarium species and contamination with fumonisin in Africa. Afr. J. Biotechnol. 2, 570–579.CrossRefGoogle Scholar
  7. 7.
    Marasas, W. F. O., Kellerman, T. S., Gelderblom, W. C. A., Coetzer, J. A. W., Thiel, P. G., Van Der Lugt, J. J. (1988) Leukoencephalomalacia in horse induced by fumonisin B1 isolated from Fusarium moniliforme. Onderstepoort J. Vet. Res. 55, 197–203.Google Scholar
  8. 8.
    NMRShiftDB Servers (2014) NMRShiftDB, Ref type: online source. Available from: Scholar
  9. 9.
    Peraica, M., Radic, B., Lucic, A., Pavlovic, M. (1999) Toxic effects of mycotoxins in humans. Bull. World Health Organ. 77, 754–766.PubMedPubMedCentralGoogle Scholar
  10. 10.
    Phillip, M., Gleeson, K., Hughes, J. M. B., Greenberg, J., Cataneo, R. N., Baker, L., McVay, W. P. (1999) Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study. Lancet 353, 1930–1933.CrossRefGoogle Scholar

Copyright information

© Akadémiai Kiadó, Budapest 2015

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  1. 1.College of Agriculture and Environmental SciencesUniversity of South AfricaFloridaSouth Africa

Personalised recommendations