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Granulocytic sarcoma presenting with malignant anasarca in a patient with secondary acute myeloid leukemia

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Abstract

Granulocytic sarcomas (GS) are rare extramedullary tumor masses composed of immature cells derived from the hematopoietic myeloid series. GS occur in 3% to 7% of cases of acute myeloid leukemia (AML) and can present before, during, or even after the diagnosis of AML. GS can involve different organs, individually or simultaneously, including the skin, lymph nodes, bone, breast, central nervous system, and lung among others. GS involving peritoneal and pleural fluids is a rare presentation. We present an unusual case of a patient with myelodysplastic syndrome whose disease progressed into a secondary AML and developed GS in the ascitic and pleural effusions as the predominant manifestation of disease progression.

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Authors and Affiliations

  1. Section of Hematology-Oncology, University of Oklahoma Health Sciences Center, 920 Stanton L.Young Blvd WP 2080, 73104, Oklahoma City, OK, USA

    Mohammad Y. Khan

  2. Cancer Care Associates, Oklahoma City, Oklahoma, USA

    Khader K. Hussein

  3. Departments of Radiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

    Max G. Walter

  4. Departments of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

    Muhammad K. Hasan & Mohamed A. Kharfan-Dabajaa

  5. Departments of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

    William Kern

Authors
  1. Mohammad Y. Khan
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  2. Khader K. Hussein
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  3. Max G. Walter
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  4. Muhammad K. Hasan
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  5. William Kern
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  6. Mohamed A. Kharfan-Dabajaa
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Corresponding author

Correspondence to Mohamed A. Kharfan-Dabajaa.

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Khan, M.Y., Hussein, K.K., Walter, M.G. et al. Granulocytic sarcoma presenting with malignant anasarca in a patient with secondary acute myeloid leukemia. Int J Hematol 79, 250–252 (2004). https://doi.org/10.1532/IJH97.NA0305

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  • DOI: https://doi.org/10.1532/IJH97.NA0305

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