A 47-year-old woman presented with severe hemolytic uremic syndrome (HUS) followed by heart failure. An echocardiogram showed an ejection fraction of 20%, and a cardiac catheterization followed by a myocardial histologic evaluation demonstrated dilated cardiomyopathy. Plasma exchange and hemodialysis were performed regularly. The later outcomes of renal function and cardiomyopathy were favorable. A review of the literature confirmed the rare and severe nature of cardiac lesions occurring in the course of HUS. This case indicates the importance of cardiac monitoring in HUS and the need for prolonged support.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Ridolfi RL, Hutchins GM, Bell WR. The heart and cardiac conduction system in thrombotic thrombocytopenic purpura: a clinicopathologic study of 17 autopsied patients.Ann Intern Med. 1979;91:357–363.
Abu-Arafeh I, Gray E, Youngson G, Auchterlonie I, Russell G. Myocarditis and haemolytic uraemic syndrome.Arch Dis Child. 1995;72:46–47.
Podolsky SH, Zembowicz A, Schoen FJ, Benjamin RJ, Sonna LA. Massive myocardial necrosis in thrombotic thrombocytopenic purpura: a case report and review of the literature.Arch Pathol Lab Med. 1999;123:937–940.
Webb JG, Butany J, Langer G, Scott G, Liu PP. Myocarditis and myocardial hemorrhage associated with thrombotic thrombocytopenic purpura.Arch Intern Med. 1990;150:1535–1537.
Wajima T, Johnson EH. Sudden cardiac death from thrombotic thrombocytopenic purpura.Clin Appl Thromb Hemost. 2000;6: 108–110.
Walker AM, Benson LN, Wilson GJ, Arbus GS. Cardiomyopathy: a late complication of hemolytic uremic syndrome.Pediatr Nephrol. 1997;11:221–222.
Gallo EG, Gianantonio CA. Extrarenal in volvement in diarrhoea-associated haemolytic-uraemic syndrome.Pediatr Nephrol. 1995;9:117–119.
Argyle JC, Hogg RJ, Pysher TJ, Silva FG, Siegler RL. A clinico-pathological study of 24 children with hemolytic uremic syndrome: a report of the Southwest Pediatric Nephrology Study Group.Pediatr Nephrol. 1990;4:52–58.
Burke AP, Mont E, Kolodgie F, Virmani R. Thrombotic thrombocytopenic purpura causing rapid unexpected death: value of CD61 immunohistochemical staining in diagnosis.Cardiovasc Pathol. 2005;14:150–155.
Ray CG, Portman JN, Stamm SJ, Hickman RO. Hemolyticuremic syndrome and myocarditis: association with coxsackievirus B infection.Am J Dis Child. 1971;122:418–420.
Poulton J, Taylor CM, De Giovanni JV. Dilated cardiomyopathy associated with haemolytic uraemic syndrome.Br Heart J. 1987;57:181–183.
Taylor CM, White RH, Winterborn MH, Rowe B. Haemolytic-uraemic syndrome: clinical experience of an outbreak in the West Midlands.BMJ. 1986;292:1513–1516.
Cosmai EM, Puzis L, Tsai HM, Lian EC. Thrombocytopenic purpura and cardiomyopathy in pregnancy reversed by combined plasma exchange and infusion.Eur J Haematol. 2002;68:239–242.
About this article
Cite this article
Alexopoulou, A., Dourakis, S.P., Zovoilis, C. et al. Dilated Cardiomyopathy during the Course of Hemolytic Uremic Syndrome. Int J Hematol 86, 333–336 (2007). https://doi.org/10.1532/IJH97.E0713
- Hemolytic uremic syndrome
- Heart failure