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International Journal of Hematology

, Volume 81, Issue 1, pp 75–76 | Cite as

Recombinant Factor VIIa is an Effective Therapy for Abdominal Surgery and Severe Thrombocytopenia: A Case Report

  • Venancio Conesa
  • Andrés Navarro-Ruiz
  • Joaquín Borrás-Blasco
  • Angela Mompel
  • Amparo GÓmez
  • Mercedes González
Case Report

Abstract

A 50-year-old woman was admitted to the emergency room. An appendectomy was done. On the sixth day the patient’s general state deteriorated and she became somnolent with jaundice due to distal obstructive choledocholithiasis. The results of laboratory tests were platelets 12 x 109/L, prothrombin time 13 seconds, international normalized ratio 1.19, activated partial thromboplastin time 31.8 seconds, and fibrinogen 8.78 g/L. There was no evidence of disseminated intravascular coagulation. In view of the patient’s clinical condition, surgery was considered to be indicated. Because it was a life-threatening situation and at the time there was no platelet concentrate available for immediate transfusion, she was treated with a single dose of recombinant factor VIIa (rFVIIa) (60 μg/kg).The dose of 60 μg/kg was selected on the basis of experience with rFVIIa in the treatment of hemophilic patients. In this case, use of rFVIIa was a valid alternative to control the bleeding in a patient with thrombocytopenia. However, despite the efficacy of the treatment, it should not be forgotten that it was used because of the unavailability of platelets and that we were dealing with a life-threatening situation. Clinical trials should be carried out to verify the safety, effectiveness, and efficiency of rFVIIa in these cases.

Key words

Recombinant factor VIIa Thrombocytopenia Hemorrhage Surgery Platelets 

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Copyright information

© The Japanese Society of Hematology 2005

Authors and Affiliations

  • Venancio Conesa
    • 1
  • Andrés Navarro-Ruiz
    • 2
  • Joaquín Borrás-Blasco
    • 2
    • 3
  • Angela Mompel
    • 1
  • Amparo GÓmez
    • 1
  • Mercedes González
    • 2
  1. 1.Hematology ServiceHospital General Universitario de ElcheElcheSpain
  2. 2.Pharmacy ServiceHospital General Universitario de ElcheElcheSpain
  3. 3.Servicio de FarmaciaHospital General Universitario de ElcheElcheSpain

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