International Journal of Hematology

, Volume 80, Issue 1, pp 91–93 | Cite as

The Effects of Desflurane on Human Platelet Aggregation In Vitro

  • Hülya Türkan
  • Cengiz Beyan
  • Lale Karabiyik
  • Derya Güner
  • Kürşat Kaptan


In view of the possible antiplatelet effects of general anesthetics, we investigated the in vitro effects of desflurane, a new inhalation agent, on platelet aggregation. For 15 patients who underwent elective operations, blood was sampled with desflurane induction before and after anesthesia but prior to surgery so that platelet aggregation in the drawn blood could be tested before desflurane anesthesia and again after exposure to the anesthetic. Platelet aggregation was measured with a whole-blood aggregometer. Adenosine diphosphate (ADP), collagen, and ristocetin were used as aggregating agents. Our results showed that aggregation in response to ADP, collagen, or ristocetin was not inhibited in patients who received desflurane anesthesia. This study with an in vitro model showed that desflurane had no influence on platelets in clinically relevant doses.

Key words

Anesthetics Desflurane Platelet aggregation Platelet function 


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Copyright information

© The Japanese Society of Hematology 2004

Authors and Affiliations

  • Hülya Türkan
    • 1
  • Cengiz Beyan
    • 2
  • Lale Karabiyik
    • 3
  • Derya Güner
    • 4
  • Kürşat Kaptan
    • 2
  1. 1.Department of Emergency MedicineClinic of AnaesthesiologyTurkey
  2. 2.Department of HaematologyGulhane Military Medical AcademyAnkaraTurkey
  3. 3.Department of AnaesthesiologyGazi UniversityTurkey
  4. 4.Department of AnaesthesiologyMinistry of Health Ankara Training and Research HospitalAnkaraTurkey

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