Abstract
We diagnosed T-cell acute lymphoblastic leukemia (T-ALL) with multiple cytogenetic abnormalities in a 17-year-old girl a year after she had received a diagnosis of acute promyelocytic leukemia (APML). After the diagnosis of APML in June 2001, the patient was treated with idarubicin and all-trans-retinoic acid. In September 1999, her younger sister also received a diagnosis of APML and to date has remained well. T-ALL after remission of APML is very rare, and only 1 such case has been reported. Possible causes include therapy-related reasons, genetic susceptibility to leukemia, and environmental exposure.
Similar content being viewed by others
References
Coleman CN, Cohen JR, Burke JS, Rosenberg SA. Lymphoblastic lymphoma in adults: results of a pilot protocol.Blood. 1981;57:679–684.
Pedersen-Bjergaard J. Acute lymphoid leukaemia with t(4;11) (q21;q23) following chemotherapy with cytostatic agents targeting at DNA-topoisomerase II.Leuk Res. 1992;16:733–735.
Liso V, Specchia G, Pannunzio A, Mestice A, Palumbo G, Biondi A. T-cell acute lymphoblastic leukaemia occurring in a patient with acute promyelocytic leukaemia.Haematologica. 1998;83:471–473.
Del Vecchio L, Finizio O, Lo Pardo C, et al. Co-ordinate expression of T-cell antigens on acute myelogenous leukemia and of myeloid antigens on T-acute lymphoblastic leukemia: speculation on a highly balanced bilinearity.Leukemia. 1991;5:815–818.
Schmidt CA, Przybylski GJ, Tietze A, Oettle H, Siegert W, Ludwig WD. Acute myeloid and T-cell acute lymphoblastic leukaemia with aberrant antigen expression exhibit similar TCRdelta gene rearrangements.Br J Haematol. 1996;92:929–936.
Dawson L, Slater RJ, Hagemeijer A, et al. Secondary T-acute lymphoblastic leukaemia mimicking blast crisis in chronic myeloid leukaemia.Br J Haematol. 1999;106:104–106.
Kuvuvilla J, Gupa V, Gill KS, Lipton JH. Association of familial leukemia with HLA Cw3: is it real?Leuk Lymphoma. 2003;44:309–311.
Hart SM, Foroni L. Core binding factor genes and human leukemia.Haematologica. 2002;87:1307–1323.
Prates V, Cobos M, Bouzas B, Napal J, Bordone J, Milone J. The first report of familial adult T-cell leukemia/lymphoma in Argentina.Leuk Lymphoma. 2000;37:225–227.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Bee, P.C., Gan, G.G., Sangkar, J.V. et al. A Case of T-Cell Acute Lymphoblastic Leukemia after Treatment of Acute Promyelocytic Leukemia. Int J Hematol 79, 358–360 (2004). https://doi.org/10.1532/IJH97.A20304
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1532/IJH97.A20304