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International Journal of Hematology

, Volume 79, Issue 4, pp 358–360 | Cite as

A Case of T-Cell Acute Lymphoblastic Leukemia after Treatment of Acute Promyelocytic Leukemia

  • P. C. Bee
  • G. G. Gan
  • J. V. Sangkar
  • A. Teh
  • K. Y. Goh
Case Report

Abstract

We diagnosed T-cell acute lymphoblastic leukemia (T-ALL) with multiple cytogenetic abnormalities in a 17-year-old girl a year after she had received a diagnosis of acute promyelocytic leukemia (APML). After the diagnosis of APML in June 2001, the patient was treated with idarubicin and all-trans-retinoic acid. In September 1999, her younger sister also received a diagnosis of APML and to date has remained well. T-ALL after remission of APML is very rare, and only 1 such case has been reported. Possible causes include therapy-related reasons, genetic susceptibility to leukemia, and environmental exposure.

Key words

Therapy-related leukemia T-cell acute lymphoblastic leukemia Acute promyelocytic leukemia Familial leukemia 

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Copyright information

© The Japanese Society of Hematology 2004

Authors and Affiliations

  • P. C. Bee
    • 1
  • G. G. Gan
    • 1
  • J. V. Sangkar
    • 1
  • A. Teh
    • 1
  • K. Y. Goh
    • 1
  1. 1.Department of Medicine, Faculty of MedicineUniversity MalayaKuala LumpurMalaysia

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