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Survivin and Leukemia

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Abstract

Survivin is a unique member of the inhibitor-of-apoptosis family. Survivin plays a role in the proliferation and survival of normal hematopoietic cells. Survivin expression is aberrantly enhanced in most cancers and hematopoietic malignancies. Survivin is an attractive therapeutic target, and various approaches to targeting survivin have been tested in vitro and in vivo.We review here progress in survivin research.

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Authors and Affiliations

  1. State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 300020, Tianjin, China

    Xiu Li Cong & Zhong Chao Han

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  1. Xiu Li Cong
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  2. Zhong Chao Han
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Correspondence to Zhong Chao Han.

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Cong, X.L., Han, Z.C. Survivin and Leukemia. Int J Hematol 80, 232–238 (2004). https://doi.org/10.1532/IJH97.A10408

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