Treatment of Hematologic Malignancies with Alternate Hemibody Irradiation Combined with High-Dose Chemotherapy: A Single-Center Experience
The objective of this study was to evaluate the clinical outcome of the treatment of hematologic malignancies with alternate hemibody irradiation (AHBI) combined with high-dose chemotherapy. Seventeen patients with hematologic malignancies were treated with AHBI combined with high-dose chemotherapy. Following high-dose chemotherapy, upper hemibody irradiation (UHBI) and lower hemibody irradiation (LHBI) were given sequentially in a dose of 6 to 9 Gy. UHBI was given 14 days (range, 12-22 days) after high-dose chemotherapy, and LHBI was performed 23 days (range, 7-34 days) after UHBI. Meanwhile, we treated a control group of 14 patients with acute lymphoblastic leukemia (ALL) with autologous hematopoietic stem cell transplantation (AHSCT). Hematopoietic reconstitution was observed in all of the patients. The median follow-up period was 927 days (range, 428-1446 days). The 3-year probabilities of disease-free survival (DFS) were 52.38% ± 13.47% for the patients in complete remission who underwent AHBI. No patient died of AHBI-related toxicity. The 3-year DFS rates for the 2 groups of patients with ALL were not significantly different (47.73% ± 17.55% in the AHBI group and 53.88% ± 14.08% in the AHSCT group; P >.05). AHBI combined with high-dose chemotherapy is a feasible approach for patients with hematologic malignancies and has the advantages of a desirable effectiveness, low costs, simple operation, and acceptable side effects.
Key wordsHematologic malignancy Alternate hemibody irradiation Stem cell transplant
Unable to display preview. Download preview PDF.
- 5.Chu J, Zhao J, Ying H, et al. Eradication of the residual leukemic cells by the regimen of alternate half body irradiation [in Chinese]. Chin J Hematol. 1994;15:236–239.Google Scholar
- 10.Mao Y, You Y, Chu J, et al. Treatment of acute lymphocytic leukemia by alternate half body irradiation: the first case report [in Chinese]. Chin J Hematol. 1996;17:585.Google Scholar
- 11.Wu Q, Ma H, Yu S, et al. Clinical observation of treatment of the residual disease in acute leukemia patients by alternate half body irradiation. Cancer. 2001;20:515–518.Google Scholar
- 13.Han M, Feng S, Li C, et al. Outcome of autologous bone marrow transplantation in 73 patients with acute leukemia [in Chinese]. Chin J Hematol. 1998;19:422–424.Google Scholar
- 17.Doubek M, Mayer J, Koristek Z. Treatment of acute lymphoblastic leukemia in adults with seven-drug induction therapy and intensive consolidation with or without autologous stem cell transplantation followed by maintenance therapy: experience of a single center [in Czech]. Cas Lek Cesk. 2002;141:122–126.PubMedGoogle Scholar