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International Journal of Hematology

, Volume 79, Issue 5, pp 462–464 | Cite as

Extramedullary Relapse Confirmed by Fluorescence In Situ Hybridization Study of an Ear Mass in Acute Promyelocytic Leukemia

  • Keun-Wook Lee
  • Jongyoun Yi
  • Tak Yun
  • Dae-Young Kim
  • Dong Soon Lee
  • Sung Sup Park
  • Han Ik Cho
  • Sung-Soo Yoon
  • Seonyang Park
  • Byoung Kook Kim
  • Noe Kyeong Kim
Article

Abstract

A 40-year-old man with acute promyelocytic leukemia (APL) achieved complete remission after induction chemotherapy combined with all-trans-retinoic acid. A mass developed in the left ear 24 months later. Relapse of APL was suspected at morphologic examination of the biopsy specimen of the ear mass, but t(15;17) and PML/RARα rearrangement were not detected by chromosomal, fluorescence in situ hybridization (FISH), or reverse transcription polymerase chain reaction analysis of bone marrow samples. FISH performed on the ear mass revealed t(15;17). To our knowledge, this case is the first reported case of extramedullary relapse of APL confirmed by FISH study of a biopsy specimen of extramedullary tissue.

Key words

Acute promyelocytic leukemia Extramedullary Ear involvement Fluorescence in situ hybridization PML/RARα 

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Copyright information

© The Japanese Society of Hematology 2004

Authors and Affiliations

  • Keun-Wook Lee
    • 1
  • Jongyoun Yi
    • 2
  • Tak Yun
    • 1
  • Dae-Young Kim
    • 1
  • Dong Soon Lee
    • 2
  • Sung Sup Park
    • 2
  • Han Ik Cho
    • 2
  • Sung-Soo Yoon
    • 1
    • 3
  • Seonyang Park
    • 1
  • Byoung Kook Kim
    • 1
  • Noe Kyeong Kim
    • 1
  1. 1.Departments of Internal MedicineSeoul National University College of MedicineSeoulRepublic of Korea
  2. 2.Laboratory MedicineSeoul National University College of MedicineKorea
  3. 3.Cancer Research InstituteSeoul National University College of MedicineKorea

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