Splenic Peliosis in a Patient with Aplastic Anemia during Danazol Therapy

Abstract

We experienced a case of danazol-induced splenic peliosis. A 42-year-old woman had taken danazol for refractory aplastic anemia for 2 years. Her anemia gradually became aggravated, and the patient complained of intermittent left upper-abdominal pain. Because computed tomography scanning showed multiple blood-filled cavities in the enlarged spleen without intraperi-toneal hemorrhage, a splenectomy was emergently performed. This report is the first of a case of splenic peliosis developing during danazol therapy for aplastic anemia. The possible association between the administration of anabolic steroids or danazol and the development of peliosis is discussed.

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Correspondence to Shunya Arai or Takashi Asai or Hiroshi Uozaki or Akira Hangaishi or Yoshinobu Kanda or Toru Motokura or Shigeru Chiba or Mineo Kurokawa.

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Arai, S., Asai, T., Uozaki, H. et al. Splenic Peliosis in a Patient with Aplastic Anemia during Danazol Therapy. Int J Hematol 86, 329–332 (2007). https://doi.org/10.1532/IJH97.07078

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Key words

  • Spleen
  • Peliosis
  • Danazol
  • Anabolic steroid
  • Aplastic anemia