Abstract
Multiple myeloma is a disease involving the clonal evolution of plasma cells that produce monoclonal immunoglobulin; however, other products, such as ammonia and amylase, reportedly are secreted by neoplastic plasma cells. We describe a patient with immunoglobulin A (IgA) myeloma who showed a high serum level of carcinoembryonic antigen (CEA) that correlated well with disease status and IgA level. We detected CEA-specific messenger RNA in plasma cells by means of a recently introduced rapid and quantitative RNA-amplification system, the transcription-reverse transcription concerted reaction system. This report is the first of a patient with a diagnosis of CEA-producing multiple myeloma.
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Kaito, K., Otsubo, H., Takahara, S. et al. Carcinoembryonic antigen—producing multiple myeloma detected by a transcription—reverse transcription concerted reaction system. Int J Hematol 85, 128–131 (2007). https://doi.org/10.1532/IJH97.06169
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DOI: https://doi.org/10.1532/IJH97.06169