Different Kinetics of wt1 and PML-RARα Gene Expression Levels during Remission Induction Therapy with All-trans Retinoic Acid Alone in Acute Promyelocytic Leukemia

We’re sorry, something doesn't seem to be working properly.

Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Warrell RP Jr, de The H, Wang ZY, Degos L. Acute promyelocytic leukemia. N Engl J Med. 1993;329:177–189.

    Article  CAS  PubMed  Google Scholar 

  2. 2.

    Mandelli F, Diverio D, Avvisati G, et al. Molecular remission in PML/RAR alpha-positive acute promyelocytic leukemia by combined all-trans retinoic acid and idarubicin (AIDA) therapy. Gruppo Italiano-Malattie Ematologiche Maligne dell’Adulto and Associazione Italiana di Ematologia ed Oncologia Pediatrica Cooperative Groups. Blood. 1997;90:1014–1021.

    CAS  PubMed  Google Scholar 

  3. 3.

    Lo Coco F, Diverio D, Avvisati G, et al. Therapy of molecular relapse in acute promyelocytic leukemia. Blood. 1999;94:2225–2229.

    CAS  PubMed  Google Scholar 

  4. 4.

    Inoue K, Sugiyama H, Ogawa H, et al. WT1 as a new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia. Blood. 1994;84:3071–3079.

    CAS  PubMed  Google Scholar 

  5. 5.

    Cilloni D, Gottardi E, De Micheli D, et al. Quantitative assessment of WT1 expression by real time quantitative PCR may be a useful tool for monitoring minimal residual disease in acute leukemia patients. Leukemia. 2002;16:2115–2121.

    Article  CAS  PubMed  Google Scholar 

  6. 6.

    Yanada M, Terakura S, Yokozawa T, et al. Multiplex real-time RT-PCR for prospective evaluation of WT1 and fusion gene transcripts in newly diagnosed de novo acute myeloid leukemia. Leuk Lymphoma. 2004;45:1803–1808.

    Article  CAS  PubMed  Google Scholar 

  7. 7.

    Ohno R, Asou N, Ohnishi K. Treatment of acute promyelocytic leukemia: strategy toward further increase of cure rate. Leukemia. 2003;17:1454–1463.

    Article  CAS  PubMed  Google Scholar 

  8. 8.

    Osumi K, Fukui T, Kiyoi H, et al. Rapid screening of leukemia fusion transcripts in acute leukemia by real-time PCR. Leuk Lymphoma. 2002;43:2291–2299.

    Article  CAS  PubMed  Google Scholar 

  9. 9.

    Ogawa H, Tamaki H, Ikegame K, et al. The usefulness of monitoring WT1 gene transcripts for the prediction and management of relapse following allogeneic stem cell transplantation in acute type leukemia. Blood. 2003;101:1698–1704.

    Article  CAS  PubMed  Google Scholar 

  10. 10.

    Tamaki H, Mishima M, Kawakami M, et al. Monitoring minimal residual disease in leukemia using real-time quantitative polymerase chain reaction for Wilms tumor gene (WT1). Int J Hematol. 2003;78:349–356.

    Article  CAS  PubMed  Google Scholar 

  11. 11.

    Sekiya M, Adachi M, Hinoda Y, et al. Downregulation of Wilms’ tumor gene (wt1) during myelomonocytic differentiation in HL60 cells. Blood. 1994;83:1876–1882.

    CAS  PubMed  Google Scholar 

  12. 12.

    Tamaki H, Ogawa H, Inoue K, et al. Increased expression of the Wilms tumor gene (WT1) at relapse in acute leukemia [letter]. Blood. 1996;88:4396–4398.

    CAS  PubMed  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding authors

Correspondence to Hiroya Tamaki or Tamotsu Yamagami or Manabu Kawakami or Eui Ho Kim or Machiko Mishima or Ichiro Kawase or Toshihiro Soma or Hiroyasu Ogawa.

About this article

Cite this article

Tamaki, H., Yamagami, T., Kawakami, M. et al. Different Kinetics of wt1 and PML-RARα Gene Expression Levels during Remission Induction Therapy with All-trans Retinoic Acid Alone in Acute Promyelocytic Leukemia. Int J Hematol 84, 468–470 (2006). https://doi.org/10.1532/IJH97.06161

Download citation

Keywords

  • Acute Leukemia
  • Acute Promyelocytic Leukemia
  • Minimal Residual Disease
  • Acute Promyelocytic Leukemia Cell
  • Japan Adult Leukemia Study Group