Skip to main content
SpringerLink
Log in

Different Kinetics of wt1 and PML-RARα Gene Expression Levels during Remission Induction Therapy with All-trans Retinoic Acid Alone in Acute Promyelocytic Leukemia

  • Letter to the editor
  • Published:
International Journal of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Warrell RP Jr, de The H, Wang ZY, Degos L. Acute promyelocytic leukemia. N Engl J Med. 1993;329:177–189.

    Article  CAS  PubMed  Google Scholar 

  2. Mandelli F, Diverio D, Avvisati G, et al. Molecular remission in PML/RAR alpha-positive acute promyelocytic leukemia by combined all-trans retinoic acid and idarubicin (AIDA) therapy. Gruppo Italiano-Malattie Ematologiche Maligne dell’Adulto and Associazione Italiana di Ematologia ed Oncologia Pediatrica Cooperative Groups. Blood. 1997;90:1014–1021.

    CAS  PubMed  Google Scholar 

  3. Lo Coco F, Diverio D, Avvisati G, et al. Therapy of molecular relapse in acute promyelocytic leukemia. Blood. 1999;94:2225–2229.

    CAS  PubMed  Google Scholar 

  4. Inoue K, Sugiyama H, Ogawa H, et al. WT1 as a new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia. Blood. 1994;84:3071–3079.

    CAS  PubMed  Google Scholar 

  5. Cilloni D, Gottardi E, De Micheli D, et al. Quantitative assessment of WT1 expression by real time quantitative PCR may be a useful tool for monitoring minimal residual disease in acute leukemia patients. Leukemia. 2002;16:2115–2121.

    Article  CAS  PubMed  Google Scholar 

  6. Yanada M, Terakura S, Yokozawa T, et al. Multiplex real-time RT-PCR for prospective evaluation of WT1 and fusion gene transcripts in newly diagnosed de novo acute myeloid leukemia. Leuk Lymphoma. 2004;45:1803–1808.

    Article  CAS  PubMed  Google Scholar 

  7. Ohno R, Asou N, Ohnishi K. Treatment of acute promyelocytic leukemia: strategy toward further increase of cure rate. Leukemia. 2003;17:1454–1463.

    Article  CAS  PubMed  Google Scholar 

  8. Osumi K, Fukui T, Kiyoi H, et al. Rapid screening of leukemia fusion transcripts in acute leukemia by real-time PCR. Leuk Lymphoma. 2002;43:2291–2299.

    Article  CAS  PubMed  Google Scholar 

  9. Ogawa H, Tamaki H, Ikegame K, et al. The usefulness of monitoring WT1 gene transcripts for the prediction and management of relapse following allogeneic stem cell transplantation in acute type leukemia. Blood. 2003;101:1698–1704.

    Article  CAS  PubMed  Google Scholar 

  10. Tamaki H, Mishima M, Kawakami M, et al. Monitoring minimal residual disease in leukemia using real-time quantitative polymerase chain reaction for Wilms tumor gene (WT1). Int J Hematol. 2003;78:349–356.

    Article  CAS  PubMed  Google Scholar 

  11. Sekiya M, Adachi M, Hinoda Y, et al. Downregulation of Wilms’ tumor gene (wt1) during myelomonocytic differentiation in HL60 cells. Blood. 1994;83:1876–1882.

    CAS  PubMed  Google Scholar 

  12. Tamaki H, Ogawa H, Inoue K, et al. Increased expression of the Wilms tumor gene (WT1) at relapse in acute leukemia [letter]. Blood. 1996;88:4396–4398.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular Medicine, Osaka University Graduate School of Medicine, Osaka

    Hiroya Tamaki, Manabu Kawakami, Eui Ho Kim, Machiko Mishima, Ichiro Kawase & Hiroyasu Ogawa

  2. Department of Medicine, National Hospital Organization Osaka Minami Medical Center, Osaka

    Hiroya Tamaki, Tamotsu Yamagami & Toshihiro Soma

  3. Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, 663-8501, Hyogo, Japan

    Hiroyasu Ogawa

Authors
  1. Hiroya Tamaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tamotsu Yamagami
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Manabu Kawakami
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Eui Ho Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Machiko Mishima
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ichiro Kawase
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Toshihiro Soma
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hiroyasu Ogawa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hiroyasu Ogawa.

About this article

Cite this article

Tamaki, H., Yamagami, T., Kawakami, M. et al. Different Kinetics of wt1 and PML-RARα Gene Expression Levels during Remission Induction Therapy with All-trans Retinoic Acid Alone in Acute Promyelocytic Leukemia. Int J Hematol 84, 468–470 (2006). https://doi.org/10.1532/IJH97.06161

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1532/IJH97.06161

Keywords

Search

Navigation