Advertisement

International Journal of Hematology

, Volume 84, Issue 3, pp 205–209 | Cite as

Regulation of Neutrophil Functions by Proinflammatory Cytokines

  • Takayuki Kato
  • Seiichi Kitagawa
Article

Abstract

Various functions of mature human neutrophils are activated or potentiated by hematopoietic growth factors or proinflammatory cytokines such as granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, tumor necrosis factor α, and interleukin 1β. The major signaling pathways activated in human neutrophils stimulated by proinflammatory cytokines include mitogen-activated protein kinases, Janus kinase/signal transducer and activator of transcription, phosphatidylinositol 3-kinase, and nuclear factor κB. These signaling pathways are involved in cytokine-mediated regulation of neutrophil functions in a cytokine-specific manner.

Key words

Neutrophil Cytokine Superoxide Migration Apoptosis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Kitagawa S, Yuo A, Souza LM, Saito M, Miura Y, Takaku F. Recombinant human granulocyte colony-stimulating factor enhances superoxide release in human granulocytes stimulated by the chemotactic peptide. Biochem Biophys Res Commun. 1987;144: 1143–1146.CrossRefGoogle Scholar
  2. 2.
    Yuo A, Kitagawa S, Ohsaka A, et al. Recombinant human granulocyte colony-stimulating factor as an activator of human granulocytes: potentiation of responses triggered by receptor-mediated agonists and stimulation of C3bi receptor expression and adherence. Blood. 1989;74:2144–2149.PubMedGoogle Scholar
  3. 3.
    Yuo A, Kitagawa S, Suzuki I, et al. Tumor necrosis factor as an activator of human granulocytes: potentiation of the metabolisms triggered by the Ca2+-mobilizing agonists. J Immunol. 1989;142: 1678–1684.PubMedGoogle Scholar
  4. 4.
    Suzuki K, Hino M, Hato F, Tatsumi N, Kitagawa S. Cytokine-specific activation of distinct mitogen-activated protein kinase subtype cascades in human neutrophils stimulated by granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor-α. Blood. 1999;93:341–349.PubMedPubMedCentralGoogle Scholar
  5. 5.
    Suzuki K, Hasegawa T, Sakamoto C, et al. Cleavage of mitogen-activated protein kinases in human neutrophils undergoing apoptosis: role in decreased responsiveness to inflammatory cytokines. J Immunol. 2001;166:1185–1192.CrossRefGoogle Scholar
  6. 6.
    Lambeth JD. NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol. 2004;4:181–189.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Hoyal CR, Gutierrez A, Young BM, et al. Modulation of p47PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase. Proc Natl Acad Sci U S A. 2003;100:5130–5135.CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Suzuki K, Hino M, Kutsuna H, et al. Selective activation of p38 mitogen-activated protein kinase cascade in human neutrophils stimulated by IL-1β. J Immunol. 2001;167:5940–5947.CrossRefGoogle Scholar
  9. 9.
    Dang PM, Stensballe A, Boussetta T, et al. A specific p47phox-serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites. J Clin Invest. 2006;116:2033–2043.CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Zhu QS, Xia L, Mills GB, Lowell CA, Touw IP, Corey SJ. G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth. Blood. 2006;107:1847–1856.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Hermans MH, Antonissen C, Ward AC, Mayen AE, Ploemacher RE, Touw IP. Sustained receptor activation and hyperproliferation in response to granulocyte colony-stimulating factor (G-CSF) in mice with a severe congenital neutropenia/acute myeloid leukemia-derived mutation in the G-CSF receptor gene. J Exp Med. 1999;189: 683–692.CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Kamata N, Kutsuna H, Hato F, et al. Activation of human neutrophils by granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-a: the role of phosphatidylinositol 3-kinase. Int J Hematol. 2004;80: 421–427.CrossRefGoogle Scholar
  13. 13.
    Chen Q, Powell DW, Rane MJ, et al. Akt phosphorylates p47phox and mediates respiratory burst activity in human neutrophils. J Immunol. 2003;170:5302–5308.CrossRefGoogle Scholar
  14. 14.
    Han H, Fuortes M, Nathan C. Critical role of the carboxyl terminus of proline-rich tyrosine kinase (Pyk2) in the activation of human neutrophils by tumor necrosis factor: separation of signals for the respiratory burst and degranulation. J Exp Med. 2003;197:63–75.CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Fuortes M, Melchior M, Han H, Lyon GJ, Nathan C. Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF. J Clin Invest. 1999;104:327–335.CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Sims JE, Gayle MA, Slack JL, et al. Interleukin 1 signaling occurs exclusively via the type I receptor. Proc Natl Acad Sci U S A. 1993;90:6155–6159.CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Takahashi T, Hato F, Yamane T, et al. Activation of human neutrophil by cytokine-activated endothelial cells. Circ Res. 2001;88: 422–429.CrossRefGoogle Scholar
  18. 18.
    Bourke E, Cassetti A, Villa A, Fadlon E, Colotta F, Mantovani A. IL-1β scavenging by the type II IL-1 decoy receptor in human neutrophils. J Immunol. 2003;170:5999–6005.CrossRefGoogle Scholar
  19. 19.
    Kutsuna H, Suzuki K, Kamata N, et al. Actin reorganization and morphological changes in human neutrophils stimulated by TNF, GM-CSF and G-CSF: role of mitogen-activated protein kinases. Am J Physiol Cell Physiol. 2004;286:C55-C64.CrossRefGoogle Scholar
  20. 20.
    Vollmer KL, Alberts JS, Carper HT, Mandell GL. Tumor necrosis factor-a decreases neutrophil chemotaxis toN-formyl-l-methionyl-l-leucyl-l-phenylalanine:analysis of single cell movement. J LeukocBiol. 1992;52:630–636.CrossRefGoogle Scholar
  21. 21.
    Peppelenbosch M, Boone E, Jones GE, et al. Multiple signal transduction pathways regulate TNF-induced actin reorganization in macrophages: inhibition of Cdc-42-mediated filopodium formation by TNF. J Immunol. 1999;162:837–845.PubMedGoogle Scholar
  22. 22.
    Nakamae-Akahori M, Kato T, Masuda S, et al. Enhanced neutrophil motility by granulocyte colony-stimulating factor: the role of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase. Immunology. In press.Google Scholar
  23. 23.
    Vial E, Pouyssegur J. Regulation of tumor cell motility by ERK mitogen-activated protein kinases. Ann N Y Acad Sci. 2004;1030:208–218.CrossRefGoogle Scholar
  24. 24.
    Alblas J, Ulfman L, Hordijk P, Koenderman L. Activation of RhoA and ROCK are essential for detachment of migrating leukocytes. Mol Biol Cell. 2001;12:2137–2145.CrossRefPubMedPubMedCentralGoogle Scholar
  25. 25.
    Sakamoto C, Suzuki K, Hato F, et al. Anti-apoptotic effect of granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor and cyclic AMP on human neutrophils: protein synthesis-dependent and protein synthesis-independent mechanisms and role of Janus kinase-STAT pathway. Int J Hematol. 2003;77:60–70.CrossRefGoogle Scholar
  26. 26.
    Epling-Burnette PK, Zhong B, Bai F, et al. Cooperative regulation of Mcl-1 by Janus kinase/STAT and phosphatidylinositol 3-kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed apoptosis in human neutrophils. J Immunol. 2001;166:7486–7495.CrossRefGoogle Scholar
  27. 27.
    Derouet M, Thomas L, Cross A, Moots RJ, Edwards SW. Granulocyte macrophage colony-stimulating factor signaling and protea-some inhibition delay neutrophil apoptosis by increasing the stability of Mcl-1. J Biol Chem. 2004;279:26915–26921.CrossRefGoogle Scholar
  28. 28.
    Cowburn AS, Cadwallader KA, Reed BJ, Farahi N, Chilvers ER. Role of PI3-kinase-dependent Bad phosphorylation and altered transcription in cytokine-mediated neutrophil survival. Blood. 2002;100:2607–2616.CrossRefGoogle Scholar
  29. 29.
    Hasegawa T, Suzuki K, Sakamoto C, et al. Expression of the inhibitor of apoptosis (IAP) family members in human neutrophils: up-regulation of cIAP2 by granulocyte colony-stimulating factor and overexpression of cIAP2 in chronic neutrophilic leukemia. Blood. 2003;101:1164–1171.CrossRefGoogle Scholar
  30. 30.
    Maianski NA, Roos D, Kuijpers TW. Bid truncation, Bid/Bax targeting to the mitochondria, and caspase activation associated with neutrophil apoptosis are inhibited by granulocyte colony-stimulating factor. J Immunol. 2004;172:7024–7030.CrossRefGoogle Scholar
  31. 31.
    Altznauer F, Martinelli S, Yousefi S, et al. Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils. J Exp Med. 2004;199:1343–1354.CrossRefPubMedPubMedCentralGoogle Scholar
  32. 32.
    Sakamoto E, Hato F, Kato T, et al. Type I and type II interferons delay human neutrophil apoptosis via activation of STAT3 and up-regulation of cellular inhibitor of apoptosis 2. J Leukoc Biol. 2005;78:301–309.CrossRefGoogle Scholar
  33. 33.
    Kato T, Sakamoto E, Kutsuna H, Kimura-Eto A, Hato F, Kitagawa S. Proteolytic conversion of STAT3α to STAT3γ in human neutrophils:role of granule-derived serine proteases. J Biol Chem. 2004;279:31076–31080.CrossRefGoogle Scholar
  34. 34.
    Wang K, Scheel-Toellner D, Wong SH, et al. Inhibition of neutrophil apoptosis by type 1 IFN depends on cross-talk between phosphoinositol 3-kinase, protein kinase C-δ, and NF-κB signaling pathways. J Immunol. 2003;171:1035–1041.CrossRefGoogle Scholar
  35. 35.
    Kilpatrick LE, Sun S, Korchak HM. Selective regulation by δ-PKC and PI 3-kinase in the assembly of the antiapoptotic TNFR-1 signaling complex in neutrophils. Am J Physiol Cell Physiol. 2004;287:C633-C642.CrossRefGoogle Scholar
  36. 36.
    Kobayashi S, Yamashita K, Takeoka T, et al. Calpain-mediated X-linked inhibitor of apoptosis degradation in neutrophil apoptosis and its impairment in chronic neutrophilic leukemia. J Biol Chem. 2002;277:33968–33977.CrossRefGoogle Scholar
  37. 37.
    Nishiki S, Hato F, Kamata N, et al. Selective activation of STAT3 in human monocytes stimulated by G-CSF: implication in inhibition of LPS-induced TNF-α production. Am J Physiol Cell Physiol. 2004;286:C1302-C1311.CrossRefGoogle Scholar
  38. 38.
    Görgen I, Hartung T, Leist M, et al. Granulocyte colony-stimulating factor treatment protects rodents against lipopolysaccharide-induced toxicity via suppression of systemic tumor necrosis factor-α. J Immunol. 1992;149:918–924.PubMedGoogle Scholar
  39. 39.
    Hartung T, Döcke WD, Gantner F, et al. Effect of granulocyte colony-stimulating factor treatment on ex vivo blood cytokine response in human volunteers. Blood. 1995;85:2482–2489.PubMedGoogle Scholar
  40. 40.
    Joshi SS, Lynch JC, Pavletic SZ, et al. Decreased immune functions of blood cells following mobilization with granulocyte colony-stimulating factor: association with donor characteristics. Blood. 2001;98:1963–1970.CrossRefGoogle Scholar
  41. 41.
    Volpi I, Perruccio K, Tosti A, et al. Postgrafting administration of granulocyte colony-stimulating factor impairs functional immune recovery in recipients of human leukocyte antigen haplotype-mis-matched hematopoietic transplants. Blood. 2001;97:2514–2521.CrossRefGoogle Scholar
  42. 42.
    Ringdén O, Remberger M, Runde V, et al. Peripheral blood stem cell transplantation from unrelated donors: a comparison with marrow transplantation. Blood. 1999;94:455–464.PubMedGoogle Scholar
  43. 43.
    Barton GM, Medzhitov R. Toll-like receptor signaling pathways. Science. 2003;300:1524–1525.CrossRefGoogle Scholar
  44. 44.
    Yamamoto M, Sato S, Hemmi H, et al. Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway. Science. 2003;301:640–643.CrossRefGoogle Scholar
  45. 45.
    Demetri GD, Griffin JD. Granulocyte colony-stimulating factor and its receptor. Blood. 1991;78:2791–2808.PubMedGoogle Scholar
  46. 46.
    Ohsaka A, Kitagawa S, Sakamoto S, et al. In vivo activation of human neutrophil functions by administration of recombinant human granulocyte colony-stimulating factor in patients with malignant lymphoma. Blood. 1989;74:2743–2748.PubMedGoogle Scholar

Copyright information

© The Japanese Society of Hematology 2006

Authors and Affiliations

  1. 1.Department of PhysiologyOsaka City University Graduate School of MedicineAsahi-machi, Abeno-ku OsakaJapan

Personalised recommendations