International Journal of Hematology

, Volume 84, Issue 3, pp 210–216 | Cite as

Fcγ Receptor Signaling in Phagocytes

  • Trupti Joshi
  • Jonathan P. Butchar
  • Susheela Tridandapani


Fcγ receptors are among the best-studied phagocytic receptors. The key features of Fcγ receptor-mediated phagocytosis include phagocytic cup formation by extensive actin cytoskeletal rearrangements, particle engulfment, and the release of proinflammatory mediators such as cytokines and reactive oxygen species. These events are elegantly regulated by the simultaneous engagement of activating and inhibitory Fcγ receptors and by intracellular signaling molecules. Extensive studies in the past several years have defined the molecular mechanisms of the phagocytic process. The purpose of this review is to revisit some of the well-established signaling pathways as well as to summarize the new findings in this field.

Key words

Fcγ receptor Phagocytosis Signaling Regulation Reactive oxygen species 


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Copyright information

© The Japanese Society of Hematology 2006

Authors and Affiliations

  • Trupti Joshi
    • 1
  • Jonathan P. Butchar
    • 1
  • Susheela Tridandapani
    • 1
  1. 1.Department of Internal MedicineDorothy M. Davis Heart and Lung Research Institute and Comprehensive Cancer Center, The Ohio State UniversityColumbusUSA

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