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International Journal of Hematology

, Volume 84, Issue 2, pp 170–173 | Cite as

Successful Treatment of Minimal Residual Disease—Positive Philadelphia Chromosome—Positive Acute Lymphoblastic Leukemia with Imatinib Followed by Reduced-Intensity Unrelated Cord Blood Transplantation after Allogeneic Peripheral Blood Stem Cell Transplantation

  • Akiyoshi Takami
  • Shigeru Shimadoi
  • Chiharu Sugimori
  • Kenichi Takemoto
  • Masami Shibayama
  • Tomotaka Yoshida
  • Tohru Murayama
  • Kenichi Nagai
  • Koichi Miyamura
  • Hidesaku Asakura
  • Shinji Nakao
Case Report

Abstract

We describe a 35-year-old woman with Philadelphia chromosome—positive acute lymphoblastic leukemia (Ph+ ALL) who received allogeneic sibling donor peripheral blood stem cell transplantation (PBSCT) and entered a second complete remission. Upon detection of BCR-ABL transcripts after PBSCT, the patient received imatinib, leading to molecular remission. Following the failure of donor leukocyte infusions, she underwent reduced-intensity unrelated cord blood transplantation (RI-UCBT), and has continued durable molecular remission for more than 30 months without substantial graft-versus-host disease. Because of a lack of adverse effects of imatinib on transplantation outcome, a treatment strategy consisting of molecular monitoring-guided initiation of imatinib followed by RI-UCBT may be promising in the management of Ph+ ALL after allogeneic SCT.

Key words

Philadelphia chromosome-positive acute lymphoblastic leukemia Unrelated cord blood transplantation Imatinib Minimal residual disease 

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Copyright information

© The Japanese Society of Hematology 2006

Authors and Affiliations

  • Akiyoshi Takami
    • 1
    • 2
  • Shigeru Shimadoi
    • 1
    • 2
  • Chiharu Sugimori
    • 1
  • Kenichi Takemoto
    • 2
  • Masami Shibayama
    • 2
  • Tomotaka Yoshida
    • 2
  • Tohru Murayama
    • 3
  • Kenichi Nagai
    • 4
  • Koichi Miyamura
    • 5
  • Hidesaku Asakura
    • 1
    • 2
  • Shinji Nakao
    • 1
    • 2
  1. 1.Department of Cellular Transplantation BiologyKanazawa University Graduate School of MedicineKanazawaJapan
  2. 2.Laboratory MedicineKanazawa University Graduate School of MedicineKanazawa
  3. 3.Department of HematologyHyogo Medical Center for AdultsAkashi
  4. 4.Department of Hematology and Clinical ImmunologyKobe City General HospitalKobe
  5. 5.Department of HematologyJapanese Red Cross Nagoya First HospitalNagoyaJapan

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