International Journal of Hematology

, Volume 84, Issue 3, pp 272–275 | Cite as

Immune-Mediated Myelopathy following Allogeneic Stem Cell Transplantation

  • Miwa Sakai
  • Kazuteru Ohashi
  • Takuya Yamashita
  • Hideki Akiyama
  • Hisashi Sakamaki
  • Keiko Ohta
  • Shuji Kisida
  • Noriko Kamata
Case report

Abstract

We report a case of immune-mediated myelopathy occurring 4 months after unrelated bone marrow transplantation for myelodysplastic syndrome. After the tapering of cyclosporine for graft-versus-host disease prophylaxis, the patient developed several neurological symptoms mimicking the clinical features of multiple sclerosis (MS).Although neurological exacerbation was well stabilized with a bulk dose of corticosteroid, sustained improvement of neurological deficits occurred after the patient developed hematopoietic mixed chimerism (HMC).This experience may provide clinical evidence supporting the current therapeutic concept, in which HMC induction can potentially cure several immune diseases, including MS.

Key words

Myelopathy Hematopoietic mixed chimerism Unrelated bone marrow transplantation 

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Copyright information

© The Japanese Society of Hematology 2006

Authors and Affiliations

  • Miwa Sakai
    • 1
  • Kazuteru Ohashi
    • 1
  • Takuya Yamashita
    • 1
  • Hideki Akiyama
    • 1
  • Hisashi Sakamaki
    • 1
  • Keiko Ohta
    • 2
  • Shuji Kisida
    • 2
  • Noriko Kamata
    • 3
  1. 1.Hematology DivisionTokyo Metropolitan Cancer and Infectious Diseases Center, Komagome HospitalBunkyo-ku, TokyoJapan
  2. 2.Neurology DivisionTokyo Metropolitan Cancer and Infectious Diseases Center, Komagome HospitalTokyoJapan
  3. 3.Radiology DivisionTokyo Metropolitan Cancer and Infectious Diseases Center, Komagome HospitalTokyoJapan

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