Acute Myelomonocytic Leukemia with Dysplastic Bone Marrow Eosinophils Showing t(5;17)(q13;q11) and a Secondary Chromosomal Aberration, inv(16)(p13q22)

Abstract

inv(16)(p13q22) is associated with de novo acute myelomonocytic leukemia with dysplastic bone marrow eosinophils (AMML Eo), which has a relatively favorable clinical course with a longer remission duration and better survival prospects. On the other hand, t(5;17)(q13;q11), although relatively rare, has been reported to be a component of complex chromosomal abnormalities in myelodysplastic syndromes and secondary acute myeloid leukemia (AML). We treated a 29-year-old woman with the first reported case of de novo AMML Eo with inv(16)(p13q22) in addition to t(5;17)(q13;q11). Although she attained complete remission (CR) immediately after induction therapy, the disease recurred 1 year after the completion of consolidation therapies. She underwent HLA-matched unrelated allogeneic bone marrow transplantation (UBMT), together with a myeloablative conditioning regimen, after achieving a second CR and has survived without a recurrence for more than 24 months since UBMT. In general, certain secondary chromosomal abnormalities are associated with the phenotype of the disease, which retains its essential biologic characteristics established by the primary abnormality.Accordingly, the primary nature of the leukemic cells in this case differs from the findings for core-binding factor AML with inv(16)(p13q22). We believe this report is the first of de novo AMML Eo with t(5;17)(q13;q11) showing as a secondary chromosomal aberration with inv(16)(p13q22).

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Misawa S, Lee E, Schiffer CA, Liu Z8, Testa JR. Association of the translocation (15;17) with the malignant proliferation of promye-locytes in acute leukemia and chronic myelogenous leukemia at blast crisis. Blood. 1986;67:270–274.

    CAS  PubMed  Google Scholar 

  2. 2.

    Scolnik MP, Paracios M, Acevedo SH, et al. Promyelocytic blast crisis of chronic myelogenous leukaemia with translocations (9;22) and (15;17). Leuk Lymphoma. 1998;31:231–236.

    CAS  PubMed  Google Scholar 

  3. 3.

    Enright H, Weisdorf D, Peterson L, Rydell RE, Kaplan ME, Arthur DC. Inversion of chromosome 16 and dysplastic eosinophils in accelerated phase of chronic myeloid leukemia. Leukemia. 1992;6:381–384.

    CAS  PubMed  Google Scholar 

  4. 4.

    Asou N, Sanada I, Tanaka K, et al. Inversion of chromosome 16 and bone marrow eosinophilia in a myelomonocytic transformation of chronic myeloid leukemia. Cancer Genet Cytogenet. 1992;61:197–200.

    Article  CAS  PubMed  Google Scholar 

  5. 5.

    Heim S, Christensen BE, Fioretos T, Sorensen AG, Pedersen NT. Acute myelomonocytic leukemia with inv(16)(p13q22) complicating Philadelphia chromosome positive chronic myeloid leukemia. Cancer Genet Cytogenet. 1992;59:35–38.

    Article  CAS  PubMed  Google Scholar 

  6. 6.

    Grimwade D, Walker H, Oliver F, et al, on behalf of the Medical Research Council Adult and Children’s Leukaemia Working Parties. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. Blood. 1998;92:2322–2333.

    CAS  PubMed  Google Scholar 

  7. 7.

    Roulston D, Espinosa R 3rd, Stoffel M, Bell GI, Le Beau MM. Molecular genetics of myeloid leukemia: identification of the commonly deleted segment of chromosome 20. Blood. 1993;82:3424–3429.

    CAS  PubMed  Google Scholar 

  8. 8.

    Soenen V, Preudhomme C, Roumier C, Daudignon A, Lai JL, Fenaux P. 17p deletion in acute myeloid leukemia and myelodysplastic syndrome: analysis of breakpoints and deleted segments by fluorescence in situ. Blood. 1998;91:1008–1015.

    CAS  PubMed  Google Scholar 

  9. 9.

    Mamuris Z, Dumont J, Dutrillaux B, Aurias A. Chromosomal differences between acute nonlymphocytic leukemia inpatients with prior solid tumors and prior hematologic malignancies: a study of 14 cases with prior breast cancer. Cancer Genet Cytogenet. 1989;42:43–50.

    Article  CAS  PubMed  Google Scholar 

  10. 10.

    Miyawaki S, Sakamaki H, Ohtake S, et al, and the Japan Adult Leukemia Study Group. A randomized, postremission comparison of four courses of standard-dose consolidation therapy without maintenance therapy versus three courses of standard-dose consolidation with maintenance therapy in adults with acute myeloid leukemia: the Japan Adult Leukemia Study Group AML97 study. Cancer. 2005;104:2726–2734.

    Article  CAS  PubMed  Google Scholar 

  11. 11.

    Le Beau MM, Larson RA, Bitter MA, Vardiman JW, Golomb HM, Rowley JD. Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia: a unique cytogenetic-clinicopathological association. N Engl J Med. 1983;309:630–636.

    Article  PubMed  Google Scholar 

  12. 12.

    Johansson B, Mertens F, Mitelman F. Secondary chromosomal abnormalities in acute leukemias. Leukemia. 1994;8:953–962.

    CAS  PubMed  Google Scholar 

  13. 13.

    Castro PD, Liang LC, Nagarajan L. Deletion of chromosome 5q13.3 and 17p loci cooperate in myeloid neoplasms. Blood. 2000;95:2138–2143.

    CAS  PubMed  Google Scholar 

  14. 14.

    Babicka L, Ransdorfova S, Brezinova J, et al. Analysis of complex chromosomal rearrangements in adult patients with MDS and AML by multicolor FISH. Leuk Res. 2006. In press.

  15. 15.

    Liang H, Samanta S, Nagarajan L. SSBP2, a candidate tumor suppressor gene, induces growth arrest and differentiation of myeloid leukemia cells. Oncogene. 2005;24:2625–2634.

    Article  CAS  PubMed  Google Scholar 

  16. 16.

    Longo L, Donti E, Mencarelli A, et al. Mapping of chromosome 17 breakpoints in acute myeloid leukemias. Oncogene. 1990;5:1557–1563.

    CAS  PubMed  Google Scholar 

  17. 17.

    Marcucci G, Mrozek K, Ruppert AS, et al. Prognostic factors and outcome of core binding factor acute myeloid leukemia patients with t(8;21) differ from those of patients with inv(16): a Cancer and Leukemia Group B study. J Clin Oncol. 2005;23:5705–5717.

    Article  PubMed  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding authors

Correspondence to Rika Sakai or Katsumichi Fujimaki or Etsuko Yamazaki or Hiroshi Sakamoto or Heiwa Kanamori or Ikuo Miura or Yoshiaki Ishigatsubo.

About this article

Cite this article

Sakai, R., Fujimaki, K., Yamazaki, E. et al. Acute Myelomonocytic Leukemia with Dysplastic Bone Marrow Eosinophils Showing t(5;17)(q13;q11) and a Secondary Chromosomal Aberration, inv(16)(p13q22). Int J Hematol 84, 417–420 (2006). https://doi.org/10.1532/IJH97.06054

Download citation

Key words

  • Acute myeloid leukemia
  • Additional chromosomal abnormality
  • inv(16)(p13q22)
  • t(5:17)(q13:q11)