International Journal of Hematology

, Volume 84, Issue 4, pp 367–376 | Cite as

Expression of CD27 on Peripheral CD4+ T-Lymphocytes Correlates with the Development of Severe Acute Graft-versus-Host Disease after Allogeneic Bone Marrow Transplantation

  • Hitoshi Yoshida
  • Tetsuo Maeda
  • Jun Ishikawa
  • Shinya Inoue
  • Hitomi Matsunaga
  • Satoru Kosugi
  • Masamichi Shiraga
  • Kenji Oritani
  • Yuzuru Kanakura
  • Yoshiaki Tomiyama


Allogeneic immune responses during hematopoietic reconstitution play central roles in beneficial and adverse effects after allogeneic bone marrow transplantation (allo-BMT).Appropriate regulation of the immune responses might improve the outcome of allo-BMT. However, a useful marker for monitoring allogeneic immune responses remains to be established. We enrolled 22 consecutive patients who underwent myeloablative allo-BMT between March 2002 and March 2006 and examined the relationship between CD27 expression on peripheral blood T-lymphocytes, a possible marker for naive/effector pheno-types, and clinical events, especially acute graft-versus-host disease (aGVHD). In 8 patients with aGVHD of grades II to IV, the CD27+/CD27- ratios of CD4+ (but not CD8+) T-lymphocytes were significantly higher after allo-BMT, even at day 21, than the ratios in patients with aGVHD of grade 0 or I and remained high after day 21. In contrast, the ratios were low after day 21 following allo-BMT in 14 patients with aGVHD of grade 0 or I. Moreover, the clinical analysis suggested a relationship between the ratio and aGVHD grade. Thus, we showed that the CD27+/CD27- ratio in CD4+ T-lymphocytes may have value in predicting the development of severe aGVHD and may correlate with clinical symptoms of aGVHD.

Key words

Allogeneic bone marrow transplantation Acute GVHD CD4+ T-lymphocytes CD27+/CD27- ratio Prediction 


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Copyright information

© The Japanese Society of Hematology 2006

Authors and Affiliations

  • Hitoshi Yoshida
    • 1
  • Tetsuo Maeda
    • 1
  • Jun Ishikawa
    • 1
  • Shinya Inoue
    • 1
  • Hitomi Matsunaga
    • 1
  • Satoru Kosugi
    • 1
  • Masamichi Shiraga
    • 1
  • Kenji Oritani
    • 1
  • Yuzuru Kanakura
    • 1
  • Yoshiaki Tomiyama
    • 1
  1. 1.Department of Hematology and Oncology, Graduate School of MedicineC9, Osaka UniversityOsakaJapan

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