International Journal of Hematology

, Volume 83, Issue 2, pp 164–178 | Cite as

Current Status of Hematopoietic Cell Transplantation for Adult Patients with Hematologic Diseases and Solid Tumors in Japan

  • Masahiro Imamura
  • Shigetaka Asano
  • Mine Harada
  • Yasuo Ikeda
  • Koji Kato
  • Shunichi Kato
  • Keisei Kawa
  • Seiji Kojima
  • Yasuo Morishima
  • Yoshihisa Morishita
  • Tatsutoshi Nakahata
  • Jun Okamura
  • Shinichiro Okamoto
  • Shintaro Shiobara
  • Mitsune Tanimoto
  • Masahiro Tsuchida
  • Yoshiko Atsuta
  • Kazuhito Yamamoto
  • Junji Tanaka
  • Nobuyuki Hamajima
  • Yoshihisa Kodera


A nationwide survey of hematopoietic cell transplantation (HCT) was started in Japan in 1991, and the analyzed survey data have been presented as the annual report of the Japan Society for Hematopoietic Cell Transplantation.The 10-year overall survival (OS) rates after HCT for each disease are as follows: acute myelogenous leukemia, 44.2%; acute lymphocytic leukemia, 33.7%; adult T-cell leukemia, 24.6%; chronic myelogenous leukemia, 53.3%; myelodysplastic syndrome, 37.3%; non-Hodgkin’s lymphoma, 41.5%; Hodgkin’s lymphoma, 50.8%; aplastic anemia, 72.5%; breast cancer, 37.1%; germ cell tumor, 52.6%; and ovarian cancer, 44.2%.The 5-year OS rates for multiple myeloma and lung cancer were 40.6% and 23.6%, respectively. Except in cord blood transplantation, engraftment was accomplished in more than 90% of patients.The respective frequencies of acute graft-versus-host disease (GVHD) and chronic GVHD were 41.1% and 34.9% for related bone marrow transplantation (BMT), 66.8% and 34.5% for unrelated BMT, 52.9% and 36.0% for allogeneic peripheral blood stem cell transplantation, and 53.3% and 32.1% for allogeneic cord blood transplantation. OS for each disease was analyzed by patient age, stem cell source, donor type, disease status, and disease type.These data provide objective and valuable information for hematologists as well as for patients who need HCT.

Key words

Hematopoietic cell transplantation Overall survival Hematologic malignancies Solid tumors Graft-versus-host disease 


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Copyright information

© The Japanese Society of Hematology 2006

Authors and Affiliations

  • Masahiro Imamura
    • 1
  • Shigetaka Asano
    • 2
  • Mine Harada
    • 3
  • Yasuo Ikeda
    • 4
  • Koji Kato
    • 5
  • Shunichi Kato
    • 6
  • Keisei Kawa
    • 7
  • Seiji Kojima
    • 8
  • Yasuo Morishima
    • 9
  • Yoshihisa Morishita
    • 10
  • Tatsutoshi Nakahata
    • 11
  • Jun Okamura
    • 12
  • Shinichiro Okamoto
    • 4
  • Shintaro Shiobara
    • 13
  • Mitsune Tanimoto
    • 14
  • Masahiro Tsuchida
    • 15
  • Yoshiko Atsuta
    • 16
  • Kazuhito Yamamoto
    • 9
  • Junji Tanaka
    • 1
  • Nobuyuki Hamajima
    • 16
  • Yoshihisa Kodera
    • 17
  1. 1.Department of Hematology and OncologyHokkaido University Graduate School of MedicineSapporoJapan
  2. 2.Consolidated Research Institute for Advanced Science and Medical CareWaseda UniversityTokyo
  3. 3.Department of Medicine and Biosystemic ScienceKyushu University Graduate School of MedicineFukuoka
  4. 4.Division of Hematology, Department of Internal MedicineKeio University School of MedicineTokyo
  5. 5.Division of Hematology and Oncology, Children’s Medical Center, Red CrossNagoya First HospitalNagoya
  6. 6.Department of Cell Transplantation and Regenerative MedicineTokai University School of MedicineKanagawa
  7. 7.Department of PediatricsOsaka Medical Center and Research Institute for Maternal and Child HealthOsaka
  8. 8.Department of Pediatrics and Developmental PediatricsNagoya University Graduate School of MedicineNagoya
  9. 9.Department of Hematology and Cell TherapyAichi Cancer Center HospitalNagoya
  10. 10.Department of Hematology and OncologyJA Aichi Showa HospitalAichi
  11. 11.Department of PediatricsGraduate School of Medicine, Kyoto UniversityKyoto
  12. 12.Institute for Clinical ResearchNational Kyushu Cancer CenterFukuoka
  13. 13.Department of Cellular Transplantation BiologyKanazawa University Graduate School of MedicineKanazawa
  14. 14.Department of Hematology and OncologyOkayama University Graduate School of Medicine and DentistryOkayama
  15. 15.Department of PediatricsIbaragi Children’s HospitalIbaragi
  16. 16.Department of Preventive Medicine/Biostatistics and Medical Decision MakingNagoya University Graduate School of MedicineNagoya
  17. 17.Department of HematologyJapanese Red Cross Nagoya First HospitalNagoyaJapan

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