Skip to main content
SpringerLink
Log in

CD7/CD19 Double-Positive T-Cell Acute Lymphoblastic Leukemia

  • Case Report
  • Published:
International Journal of Hematology Aims and scope Submit manuscript

Abstract

We report a rare case of T-cell acute lymphoblastic leukemia (T-ALL) with an aberrant phenotype. A 52-year-old man was admitted to our hospital because of lymph node (LN) swelling in the bilateral neck. A computed tomographic scan showed LN swelling in the mediastinum and a right pleural effusion. The tumor cells in the neck LN showed positivity for cytoplasmic CD3, CD7, CD19, and CD79a, whereas the tumor cells in the bone marrow (BM) showed positivity for CD10 and CD13 in addition to the former 4 antigens. The chromosomes in the BM were normal. Neither T-cell receptor γ nor immunoglobulin heavy chain rearrangement was detected in the neck LN. We diagnosed this case as T-ALL with an aberrant phenotype and started the standard chemotherapy for ALL. The response was so effective that complete remission (CR) was easily attained. The patient is now under maintenance therapy in the first CR without hematopoietic cell transplantation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Vodinelich L, Tax W, Bai Y, Pegram S, Capel P, Greaves MF. A monoclonal antibody (WT1) for detecting leukemias of T-cell precursors (T-ALL). Blood. 1983;62:1108–1113.

    CAS  PubMed  Google Scholar 

  2. Nadler LM, Korsmeyer SJ, Anderson KC, et al. B cell origin of non-T cell acute lymphoblastic leukemia: a model for discrete stages of neoplastic and normal pre-B cell differentiation. J Clin Invest. 1984;74:332–340.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  3. Lau LG, Tan LK, Koay ES, Ee MH, Tan SH, Liu TC. Acute lym-phoblastic leukemia with the phenotype of a putative B-cell/T-cell bipotential precursor. Am J Hematol. 2004;77:156–160.

    Article  PubMed  Google Scholar 

  4. Mizutani M, Miwa H, Takahashi T, et al. Cellular characteristics of acute leukemia cells simultaneously expressing CD13/CD33, CD7 and CD19. Int J Hematol. 1997;66:479–491.

    Article  CAS  PubMed  Google Scholar 

  5. Matutes E, Morilla R, Farahat N, et al. Definition of acute biphe-notypic leukemia. Haematologica. 1997;82:64–66.

    CAS  PubMed  Google Scholar 

  6. Bene MC, Castoldi G, Knapp W, et al. Proposals for the immunological classification of acute leukemias: European Group for the Immunological Characterization of Leukemias (EGIL). Leukemia. 1995;9:1783–1786.

    CAS  PubMed  Google Scholar 

  7. EGIL(European Group for the Immunological Classification of Leukaemias). The value of c-kit in the diagnosis of biphenotypic acute leukemia. Leukemia. 1998;12:2038.

    Article  Google Scholar 

  8. Akashi K, Shibuya T, Nakamura M, Oogami A, Harada M, Niho Y. Large granular lymphocytic leukaemia with a mixed T-cell/B-cell phenotype. Br J Haematol. 1998;100:291–294.

    Article  CAS  PubMed  Google Scholar 

  9. Kondo M, Weissman IL, Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell. 1997;91:661–672.

    Article  CAS  PubMed  Google Scholar 

  10. Drakos E, Rassidakis GZ, Tsioli P, Lai R, Jones D, Medeiros LJ. Differential expression of WT1 gene product in non-Hodgkin lymphomas. Appl Immunohistochem Mol Morphol. 2005;13:132–137.

    Article  CAS  PubMed  Google Scholar 

  11. Pinsky SM, Henkin RE. Gallium-67 tumor scanning. Semin Nucl Med. 1976;6:397–409.

    Article  CAS  PubMed  Google Scholar 

  12. Hodges E, Krishna MT, Pickard C, Smith JL. Diagnostic role of tests for T cell receptor (TCR) genes. J Clin Pathol. 2003;56:1–11.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Hematology, Hamamatsu Medical Center, Tomitsuka-cho 328, 432-8580, Hamamatsu, Japan

    Shinya Fujisawa, Kensuke Naito & Masahide Kobayashi

  2. Departments of Laboratory Medicine, Hamamatsu Medical Center, Hamamatsu

    Toshihiko Matsuoka

  3. Departments of Pathology, Hamamatsu Medical Center, Hamamatsu

    Takachika Ozawa

  4. Department of Pathology, Iwata City Hospital, Iwata, Japan

    Fumihiko Tanioka

Authors
  1. Shinya Fujisawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Fumihiko Tanioka
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Toshihiko Matsuoka
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Takachika Ozawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kensuke Naito
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Masahide Kobayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shinya Fujisawa.

About this article

Cite this article

Fujisawa, S., Tanioka, F., Matsuoka, T. et al. CD7/CD19 Double-Positive T-Cell Acute Lymphoblastic Leukemia. Int J Hematol 83, 324–327 (2006). https://doi.org/10.1532/IJH97.05130

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1532/IJH97.05130

Key words

Search

Navigation