CD4+CD3-Cells Regulate the Organization of Lymphoid Tissue and T-Cell Memory for Antibody Responses
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This review highlights the role of a CD4+CD3- accessory cell in the development of organized lymphoid infrastructures as well as in the development of high-affinity antibody responses and T-cell memory. These 2 functions are linked in the development of the vertebrate immune system and are effected by the constitutive expression of 2 sets of tumor necrosis factor (TNF) family members. The expression of lymphotoxin α (LTα), LTβ, and TNF-α, which are closely linked genetically, affects the organization of lymphoid structures into B-cell and T-cell areas; the dual expression of OX40 ligand (TNFSF4) and CD30 ligand (TNFSF8) influences both the survival of T-cells within germinal centers and T-cell memory. IntJHematol. 2006;83:12-16. doi: 10.1532/IJH97.05117
Key wordsCD4+CD3- cells Inducer cells CD30 OX40 Memory
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