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International Journal of Hematology

, Volume 82, Issue 2, pp 124–126 | Cite as

A Family with Hemoglobin Hirosaki

  • Yoshinori Tanaka
  • Kumiko Matsui
  • Kazuhiro Matsuda
  • Kenji Shinohara
  • Keiko Haranob
Case Report

Abstract

A 48-year-old man had a 30-year history of hemolytic anemia of undetermined cause. Spherocytes were not observed, osmotic fragility was normal, and red cell enzyme activities were normal. His brother and daughter also had hemolytic anemia. The brother had previously undergone splenectomy, and the anemia had been ameliorated. In the proband and daughter, no abnormal hemoglobin was apparent in the results of isoelectric focusing and DEAE anion-exchange high-performance liquid chromatography analyses. On evaluation with the isopropanol test, unstable hemoglobin was not observed in the proband but was detected in the daughter. There was also a decreased ratio of β globin/a globin chain production. Analysis of the α2 gene demonstrated the presence of a mutation (α43 [CE1] Phe → Leu), hemoglobin Hirosaki.

Key words

Hemolytic anemia Hemoglobinopathy Hb Hirosaki 

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Copyright information

© The Japanese Society of Hematology 2005

Authors and Affiliations

  • Yoshinori Tanaka
    • 1
  • Kumiko Matsui
    • 1
  • Kazuhiro Matsuda
    • 1
  • Kenji Shinohara
    • 1
  • Keiko Haranob
    • 2
  1. 1.Division of Hematology, Department of MedicineYamaguchi Prefecture Central HospitalHofuJapan
  2. 2.Department of Clinical Nutrition, Faculty of Health Science and TechnologyKawasaki University of Medical WelfareKurashikiJapan

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