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High Incidence of α-Thalassemia, Hemoglobin E, and Glucose-6-Phosphate Dehydrogenase Deficiency in Populations of Malaria-Endemic Southern Shan State, Myanmar

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Abstract

Samples from 916 members of various ethnic groups from malaria-endemic southern Shan State, Myanmar, were analyzed for α-thalassemia (α-thal), β -thalassemia (β -thal), abnormal hemoglobin variants, and glucose-6-phosphate dehydrogenase (G6PD) deficiency. Of these subjects, 530 (57.9%) were found to have at least one of these red cell genetic disorders.The overall frequencies for the various red cell genetic disorders were as follows: α-thal, 37.5% (343/916); hemoglobin E (Hb-E), 20.3% (186/916); G6PD-Mahidol, 17.5% (160/916); and β-thal, 0.3% (3/916). The frequencies of combined disorders were 6.9% (63/ 916) for α-thal/Hb-E, 5.7% (52/916) for α-thal/G6PD-Mahidol, 2.8% (26/916) for Hb-E/G6PD-Mahidol, 1.1% (10/916) for α-thal/Hb-E/G6PD-Mahidol, and 0.1% (1/916) for α-thal/β-thal/G6PD-Mahidol. Of the various ethnic and non-ethnic groups, the Bamar population showed the highest frequencies of α-thal (56.9%, 177/311), Hb-E (28.3%, 88/311), and G6PD-Mahidol (21.2%, 66/311) (all duplicated and triplicated cases were included). In addition, 2 new mutations, an a gene triplication (/αααanti3.7; 0.2%, 2/916) and Hb-Neapolis (0.1%, 1/916), were detected. Our results showed that race was the dominant factor affecting the frequencies of red cell genetic disorders in malaria-endemic areas of Myanmar.

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Authors and Affiliations

  1. Department of Pathological Research, Faculty of Medicine, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-Cho, Okayama, 700-8558, Okayama, Japan

    Aung Myint Than, Tetsuya Ogino & Shigeru Okadaa

  2. Department of Biochemistry, Kawasaski Medical School, Kurashiki, Japan

    Teruo Harano & Keiko Harano

  3. Department of Pathology, University of Medicine II, Yangon, Myanmar

    Aye Aye Myint

Authors
  1. Aung Myint Than
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  2. Teruo Harano
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  3. Keiko Harano
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  4. Aye Aye Myint
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  5. Tetsuya Ogino
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  6. Shigeru Okadaa
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Correspondence to Shigeru Okadaa.

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Than, A.M., Harano, T., Harano, K. et al. High Incidence of α-Thalassemia, Hemoglobin E, and Glucose-6-Phosphate Dehydrogenase Deficiency in Populations of Malaria-Endemic Southern Shan State, Myanmar. Int J Hematol 82, 119–123 (2005). https://doi.org/10.1532/IJH97.05028

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  • DOI: https://doi.org/10.1532/IJH97.05028

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