A 59-year-old man was a potential donor for allogeneic hematopoietic stem cell transplantation and was found to be healthy but slightly polycythemic. The bone marrow was morphologically normal, but karyotyping of bone marrow cells showed t(6;10)(q27;q22) in 7 of 20 metaphases analyzed by G-banding and only the t(6;10) abnormality in 3 of 5 metaphases analyzed by the spectral karyotyping method. G-banding analysis of peripheral blood mononuclear cells cultured with phyto-hemagglutinin for 72 hours showed a normal karyotype in all 20 metaphases analyzed. These findings suggest clonal expansion with t(6;10)(q27;q22) in the bone marrow of this individual. He was determined to be ineligible for donation. A coordinated nationwide work-up for older donors is necessary to ensure high-quality standards.
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Niederwieser D, Appelbaum FR, Gastl G, et al. Inadvertent transmission of a donor’s acute myeloid leukemia in bone marrow transplantation for chronic myelocytic leukemia.N Engl J Med. 1990;322:1794–1796.
Baron F, Dresse M-F, Beguin Y. Transmission of chronic myeloid leukemia through peripheral-blood stem-cell transplantation.N Engl J Med. 2003;349:913–914.
Berg KD, Brinster NK, Huhn KM et al. Transmission of a T-cell lymphoma by allogeneic bone marrow transplantation.N Engl J Med. 2001;345:1458–1463.
Kiss TL, Chang H, Daly A, et al. Bone marrow aspirates as part of routine donor assessment for allogeneic blood and marrow transplantation can reveal presence of occult hematological malignancies in otherwise asymptomatic individuals.Bone Marrow Transplant. 2004;33:855–858.
Swolin B, Weinfeld A, Westin J. A prospective long-term cytogenetic study in polycythemia vera in relation to treatment and clinical course.Blood. 1988;72:386–395.
Berger R, Bernheim A, Le Coniat M, et al. Chromosome studies in polycythemia vera patients.Cancer Genet Cytogenet. 1984;12:217–223.
Rege-Cambrin G, Mecucci C, Tricot G, et al. A chromosomal profile of polycythemia vera.Cancer Genet Cytogenet. 1987;25:233–245.
Diez-Martin JL, Graham DL, Petitt RM, Dewald GW. Chromosome studies in 104 patients with polycythemia vera.Mayo Clin Proc. 1991;66:287–299.
Testa JR. Cytogenetic patterns in polycythemia vera.Cancer Genet Cytogenet. 1980;1:207–215.
Macdonald D, Aguiar RCT, Mason PJ, Goldman JM, Cross NCP. A new myeloproliferative disorder associated with chromosomal translocations involving 8q11: a review.Leukemia 1995;9:1628–1630.
Popovici C, Zhang B, Gregoire M-J, et al. The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene,FOP, tofibroblast growth factor receptor 1.Blood. 1999;93:1381–1389.
Guasch G, Ollendorff V, Borg JP, Birnbaum D, Pebusque MJ. 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways.Mol Cell Biol. 2001;21:8129–8142.
Guasch G, Delaval B, Arnoulet C, et al. FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice.Blood. 2004;103:309–312.
Vizmanos JL, Hernandez R, Vidal MJ, et al. Clinical variability of patients with the t(6;8)(q27;p12) and FGFR1OP-FGFR1 fusion: two further cases.Hematol J. 2004;5:534–537.
Ono R, Taki T, Taketani T, et al.LCX, leukemia-associated protein with a CXXC domain, is fused toMLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23).Cancer Res. 2002;62:4075–4080.
Niederwieser D, Gentilini C, Hegenbart U, et al. Transmission of donor illness by stem cell transplantation: should screening be different in older donors?Bone Marrow Transplant. 2004;34:657–665.
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Mitsui, H., Saito, N., Satake, A. et al. A Novel Chromosomal Abnormality, t(6;10)(q27;q22), Found in a Polycythemic Potential Donor for Allogeneic Hematopoietic Stem Cell Transplantation. Int J Hematol 82, 72–74 (2005). https://doi.org/10.1532/IJH97.05027