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International Journal of Hematology

, Volume 82, Issue 1, pp 72–74 | Cite as

A Novel Chromosomal Abnormality, t(6;10)(q27;q22), Found in a Polycythemic Potential Donor for Allogeneic Hematopoietic Stem Cell Transplantation

  • Hideki Mitsui
  • Norimitsu Saito
  • Atsushi Satake
  • Tsuyoshi Nakazawa
  • Takahiro Karasuno
  • Akira Hiraoka
Case report
  • 31 Downloads

Abstract

A 59-year-old man was a potential donor for allogeneic hematopoietic stem cell transplantation and was found to be healthy but slightly polycythemic. The bone marrow was morphologically normal, but karyotyping of bone marrow cells showed t(6;10)(q27;q22) in 7 of 20 metaphases analyzed by G-banding and only the t(6;10) abnormality in 3 of 5 metaphases analyzed by the spectral karyotyping method. G-banding analysis of peripheral blood mononuclear cells cultured with phyto-hemagglutinin for 72 hours showed a normal karyotype in all 20 metaphases analyzed. These findings suggest clonal expansion with t(6;10)(q27;q22) in the bone marrow of this individual. He was determined to be ineligible for donation. A coordinated nationwide work-up for older donors is necessary to ensure high-quality standards.

Key words

Polycythemia t(6,10)(q27,q22) Donor 

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Copyright information

© The Japanese Society of Hematology 2005

Authors and Affiliations

  • Hideki Mitsui
    • 1
  • Norimitsu Saito
    • 1
  • Atsushi Satake
    • 1
  • Tsuyoshi Nakazawa
    • 1
  • Takahiro Karasuno
    • 1
  • Akira Hiraoka
    • 1
  1. 1.Department of Hematology/OncologyOsaka Medical Center for Cancer and Cardiovascular DiseasesOsakaJapan

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