International Journal of Hematology

, Volume 82, Issue 1, pp 72–74 | Cite as

A Novel Chromosomal Abnormality, t(6;10)(q27;q22), Found in a Polycythemic Potential Donor for Allogeneic Hematopoietic Stem Cell Transplantation

  • Hideki Mitsui
  • Norimitsu Saito
  • Atsushi Satake
  • Tsuyoshi Nakazawa
  • Takahiro Karasuno
  • Akira Hiraoka
Case report


A 59-year-old man was a potential donor for allogeneic hematopoietic stem cell transplantation and was found to be healthy but slightly polycythemic. The bone marrow was morphologically normal, but karyotyping of bone marrow cells showed t(6;10)(q27;q22) in 7 of 20 metaphases analyzed by G-banding and only the t(6;10) abnormality in 3 of 5 metaphases analyzed by the spectral karyotyping method. G-banding analysis of peripheral blood mononuclear cells cultured with phyto-hemagglutinin for 72 hours showed a normal karyotype in all 20 metaphases analyzed. These findings suggest clonal expansion with t(6;10)(q27;q22) in the bone marrow of this individual. He was determined to be ineligible for donation. A coordinated nationwide work-up for older donors is necessary to ensure high-quality standards.

Key words

Polycythemia t(6,10)(q27,q22) Donor 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Niederwieser D, Appelbaum FR, Gastl G, et al. Inadvertent transmission of a donor’s acute myeloid leukemia in bone marrow transplantation for chronic myelocytic leukemia.N Engl J Med. 1990;322:1794–1796.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Baron F, Dresse M-F, Beguin Y. Transmission of chronic myeloid leukemia through peripheral-blood stem-cell transplantation.N Engl J Med. 2003;349:913–914.CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Berg KD, Brinster NK, Huhn KM et al. Transmission of a T-cell lymphoma by allogeneic bone marrow transplantation.N Engl J Med. 2001;345:1458–1463.CrossRefGoogle Scholar
  4. 4.
    Kiss TL, Chang H, Daly A, et al. Bone marrow aspirates as part of routine donor assessment for allogeneic blood and marrow transplantation can reveal presence of occult hematological malignancies in otherwise asymptomatic individuals.Bone Marrow Transplant. 2004;33:855–858.CrossRefGoogle Scholar
  5. 5.
    Swolin B, Weinfeld A, Westin J. A prospective long-term cytogenetic study in polycythemia vera in relation to treatment and clinical course.Blood. 1988;72:386–395.PubMedGoogle Scholar
  6. 6.
    Berger R, Bernheim A, Le Coniat M, et al. Chromosome studies in polycythemia vera patients.Cancer Genet Cytogenet. 1984;12:217–223.CrossRefGoogle Scholar
  7. 7.
    Rege-Cambrin G, Mecucci C, Tricot G, et al. A chromosomal profile of polycythemia vera.Cancer Genet Cytogenet. 1987;25:233–245.CrossRefPubMedGoogle Scholar
  8. 8.
    Diez-Martin JL, Graham DL, Petitt RM, Dewald GW. Chromosome studies in 104 patients with polycythemia vera.Mayo Clin Proc. 1991;66:287–299.CrossRefPubMedGoogle Scholar
  9. 9.
    Testa JR. Cytogenetic patterns in polycythemia vera.Cancer Genet Cytogenet. 1980;1:207–215.CrossRefGoogle Scholar
  10. 10.
    Macdonald D, Aguiar RCT, Mason PJ, Goldman JM, Cross NCP. A new myeloproliferative disorder associated with chromosomal translocations involving 8q11: a review.Leukemia 1995;9:1628–1630.PubMedGoogle Scholar
  11. 11.
    Popovici C, Zhang B, Gregoire M-J, et al. The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene,FOP, tofibroblast growth factor receptor 1.Blood. 1999;93:1381–1389.PubMedGoogle Scholar
  12. 12.
    Guasch G, Ollendorff V, Borg JP, Birnbaum D, Pebusque MJ. 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways.Mol Cell Biol. 2001;21:8129–8142.CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Guasch G, Delaval B, Arnoulet C, et al. FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice.Blood. 2004;103:309–312.CrossRefPubMedGoogle Scholar
  14. 14.
    Vizmanos JL, Hernandez R, Vidal MJ, et al. Clinical variability of patients with the t(6;8)(q27;p12) and FGFR1OP-FGFR1 fusion: two further cases.Hematol J. 2004;5:534–537.CrossRefPubMedGoogle Scholar
  15. 15.
    Ono R, Taki T, Taketani T, et al.LCX, leukemia-associated protein with a CXXC domain, is fused toMLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23).Cancer Res. 2002;62:4075–4080.PubMedGoogle Scholar
  16. 16.
    Niederwieser D, Gentilini C, Hegenbart U, et al. Transmission of donor illness by stem cell transplantation: should screening be different in older donors?Bone Marrow Transplant. 2004;34:657–665.CrossRefPubMedGoogle Scholar

Copyright information

© The Japanese Society of Hematology 2005

Authors and Affiliations

  • Hideki Mitsui
    • 1
  • Norimitsu Saito
    • 1
  • Atsushi Satake
    • 1
  • Tsuyoshi Nakazawa
    • 1
  • Takahiro Karasuno
    • 1
  • Akira Hiraoka
    • 1
  1. 1.Department of Hematology/OncologyOsaka Medical Center for Cancer and Cardiovascular DiseasesOsakaJapan

Personalised recommendations