International Journal of Hematology

, Volume 81, Issue 2, pp 89–93 | Cite as

Bone Marrow Transplantation from the Personal Viewpoint

  • E. Donnall Thomas
Review Article


Human Leukocyte Antigen Hematopoietic Cell Transplantation Human Leukocyte Antigen Type Marrow Graft Allogeneic Marrow 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Murray JE. The first successful organ transplants in man. In: Frängsmyr T, Lundeberg B, eds. The Nobel Prizes. Stockholm: Norstedts Tryckeri AB; 1992:204–214.Google Scholar
  2. 2.
    Jacobson LO, Simmons EL, Marks EK, Eldredge JH. Recovery from radiation injury. Science. 1951;113:510–511.CrossRefPubMedGoogle Scholar
  3. 3.
    Lorenz E, Uphoff D, Reid TR, Shelton E. Modification of irradiation injury in mice and guinea pigs by bone marrow injections. J Natl Cancer Inst. 1951;12:197–201.PubMedGoogle Scholar
  4. 4.
    Main JM, Prehn RT. Successful skin homografts after the administration of high dosage X radiation and homologous bone marrow. J Natl Cancer Inst. 1955;15:1023–1029.PubMedGoogle Scholar
  5. 5.
    Thomas ED, Lochte HL Jr, Lu WC, Ferrebee JW. Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy. N Engl J Med. 1957;257:491–496.CrossRefPubMedGoogle Scholar
  6. 6.
    Ferrebee JW, Thomas ED. Factors affecting the survival of transplanted tissues. Am J Med Sci. 1958;235:369–386.CrossRefPubMedGoogle Scholar
  7. 7.
    Billingham RE, Brent L, Medawar PB. “Actively acquired tolerance” of foreign cells. Nature. 1953;172:603–606.CrossRefPubMedGoogle Scholar
  8. 8.
    Billingham RE, Brent L. Quantitative studies on tissue transplantation immunity. IV. Induction of tolerance in newborn mice and studies on the phenomenon of runt disease. Philos Trans R Soc Lond B Biol Sci. 1959;242:477.CrossRefGoogle Scholar
  9. 9.
    Barnes DWH, Loutit JF. What is the recovery factor in spleen? Nucleonics. 1954;12:68–71.Google Scholar
  10. 10.
    Ford CE, Hamerton JL, Barnes DWH, Loutit JF. Cytological identification of radiation-chimaeras. Nature. 1956;177:452–454.CrossRefPubMedGoogle Scholar
  11. 11.
    Barnes DWH, Corp MJ, Loutit JF, Neal FE. Treatment of murine leukaemia with x-rays and homologous bone marrow. Preliminary communication. Br Med J. 1956;2:626–627.CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Amiel J-L, Mathé G, Schwarzenberg L, et al. Les greffes de moelle osseuse allogénique aprés conditionnement par le seul sérum antilymphocytaire dans les états d’aplasie médullaire. La Presse Medicale. 1970;78:1727–1734.PubMedGoogle Scholar
  13. 13.
    Andrews GA. Criticality accidents in Vinca, Yugoslavia, and Oak Ridge Tennessee. Am J Roentgenol Radium Ther Nucl Med. 1965;93:56–74.PubMedGoogle Scholar
  14. 14.
    Bortin MM. A compendium of reported human bone marrow transplants. Transplantation. 1970;9:571–587.CrossRefPubMedGoogle Scholar
  15. 15.
    Thomas ED, Lochte HL Jr, Cannon JH, Sahler OD, Ferrebee JW. Supralethal whole body irradiation and isologous marrow transplantation in man. J Clin Invest. 1959;38:1709–1716.CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Thomas ED, Collins JA, Herman EC Jr, Ferrebee JW. Marrow transplants in lethally irradiated dogs given methotrexate. Blood. 1962;19:217–228.PubMedGoogle Scholar
  17. 17.
    Cavins JA, Scheer SC, Thomas ED, Ferrebee JW. The recovery of lethally irradiated dogs given infusions of autologous leukocytes preserved at -80 C. Blood. 1964;23:38–43.PubMedGoogle Scholar
  18. 18.
    Mannick JA, Lochte HL, Jr., Ashley CA, Thomas ED, Ferrebee JW. A functioning kidney homotransplant in the dog. Surgery. 1959;46:821–828.PubMedGoogle Scholar
  19. 19.
    Kasakura S, Thomas ED, Ferrebee JW. Leukocytotoxic isoantibodies in the dog. Transplantation. 1964;2:274–280.CrossRefPubMedGoogle Scholar
  20. 20.
    Epstein RB, Storb R, Ragde H, Thomas ED. Cytotoxic typing antisera for marrow grafting in littermate dogs. Transplantation. 1968;6:45–58.CrossRefPubMedGoogle Scholar
  21. 21.
    Storb R, Epstein RB, Bryant J, Ragde H, Thomas ED. Marrow grafts by combined marrow and leukocyte infusions in unrelated dogs selected by histocompatibility typing. Transplantation. 1968;6:587–593.CrossRefPubMedGoogle Scholar
  22. 22.
    Storb R, Rudolph RH, Thomas ED. Marrow grafts between canine siblings matched by serotyping and mixed leukocyte culture. J Clin Invest. 1971;50:1272–1275.CrossRefPubMedPubMedCentralGoogle Scholar
  23. 23.
    Miescher PP, Fauconnet M. Mise en évidence de différents groupes leucocytaires chez l homme. Schweiz Med Wochenschr. 1954;84:597–599.Google Scholar
  24. 24.
    Dausset J. Iso-leuco-anticorps. Acta Haematol. 1958;20:156–166.CrossRefPubMedGoogle Scholar
  25. 25.
    van Rood JJ, Eernisse JG, van Leeuwen A. Leukocyte antibodies in sera from pregnant women. Nature. 1958;181:1735–1736.CrossRefGoogle Scholar
  26. 26.
    Singal DP, Mickey MR, Terasaki PI. Serotyping for homotransplantation: XXIII analysis of kidney transplants from parental versus sibling donors. Transplantation. 1969;7:246–258.CrossRefPubMedGoogle Scholar
  27. 27.
    Mickelson E, Petersdorf EW. Histocompatibility. In: Blume KG, Forman SJ, Appelbaum FR, eds. Thomas’ Hematopoietic Cell Transplantation. Oxford, UK: Blackwell Publishing Ltd; 2004:31–42.Google Scholar
  28. 28.
    Gatti RA, Meuwissen HJ, Allen HD, Hong R, Good RA. Immunological reconstitution of sex-linked lymphopenic immunological deficiency. Lancet. 1968;2:1366–1369.CrossRefPubMedGoogle Scholar
  29. 29.
    Bach FH, Albertini RJ, Joo P,Anderson JL, Bortin MM. Bone-marrow transplantation in a patient with the Wiskott-Aldrich syndrome. Lancet. 1968;2:1364–1366.CrossRefPubMedGoogle Scholar
  30. 30.
    de Koning J, van Bekkum DW, Dicke KA, Dooren LJ, Radl J, van Rood JJ.Transplantation of bone-marrow cells and fetal thymus in an infant with lymphopenic immunological deficiency. Lancet. 1969;1:1223–1227.CrossRefPubMedGoogle Scholar
  31. 31.
    Bortin MM, Bach FH, van Bekkum DW, Good RA, van Rood JJ. 25th anniversary of the first successful allogeneic bone marrow transplants. Bone Marrow Transplant. 1994;14:211–212.PubMedGoogle Scholar
  32. 32.
    Buckner CD, Epstein RB, Rudolph RH, Clift RA, Storb R,Thomas ED. Allogeneic marrow engraftment following whole body irradiation in a patient with leukemia. Blood. 1970;35:741–750.PubMedGoogle Scholar
  33. 33.
    Thomas ED, Buckner CD, Storb R, et al. Aplastic anaemia treated by marrow transplantation. Lancet. 1972;1:284–289.CrossRefPubMedGoogle Scholar
  34. 34.
    Johnson FL, Look AT, Gockerman J, Ruggiero MR, Dalla-Pozza L, Billings FT III. Bone-marrow transplantation in a patient with sickle-cell anemia. N Engl J Med. 1984;311:780–783.CrossRefPubMedPubMedCentralGoogle Scholar
  35. 35.
    Thomas ED, Buckner CD, Sanders JE, et al. Marrow transplantation for thalassaemia. Lancet. 1982;2:227–229.CrossRefPubMedPubMedCentralGoogle Scholar
  36. 36.
    Thomas ED, Storb R, Clift RA, et al. Bone-marrow transplantation. N Engl J Med. 1975;292:832–843, 895–902.CrossRefGoogle Scholar
  37. 37.
    Thomas ED, Buckner CD, Banaji M, et al. One hundred patients with acute leukemia treated by chemotherapy, total body irradiation, and allogeneic marrow transplantation. Blood. 1977;49:511–533.PubMedPubMedCentralGoogle Scholar
  38. 38.
    Thomas ED, Flournoy N, Buckner CD, et al. Cure of leukemia by marrow transplantation. Leuk Res. 1977;1:67–70.CrossRefGoogle Scholar
  39. 39.
    Thomas ED, Buckner CD, Clift RA, et al. Marrow transplantation for acute nonlymphoblastic leukemia in first remission. N Engl J Med. 1979;301:597–599.CrossRefGoogle Scholar
  40. 40.
    Blume KG, Beutler E. Allogeneic bone marrow transplantation for acute leukemia [Letter]. JAMA. 1979;241:1686.CrossRefPubMedGoogle Scholar
  41. 41.
    Clift RA,Thomas ED. Follow-up 26 years after treatment for acute myelogenous leukemia. N Engl J Med. 2004; 351: 2456–2457.CrossRefPubMedGoogle Scholar
  42. 42.
    Mathé G, Amiel JL, Schwarzenberg L, Catton A, Schneider M. Adoptive immunotherapy of acute leukemia: experimental and clinical results. Cancer Res. 1965;25:1525–1531.Google Scholar
  43. 43.
    Weiden PL, Flournoy N, Thomas ED, et al. Antileukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts. N Engl J Med. 1979;300:1068–1073.CrossRefGoogle Scholar
  44. 44.
    Kolb H-J. Management of relapse after hematopoietic cell transplantation. In: Thomas ED, Blume KG, Forman SJ, eds. Hematopoietic Cell Transplantation, 2nd Ed. Boston: Blackwell Science;1999:929–936.Google Scholar
  45. 45.
    Goodman JW, Hodgson GS. Evidence for stem cells in the peripheral blood of mice. Blood. 1962;19:702–714.PubMedGoogle Scholar
  46. 46.
    Storb R, Buckner CD, Epstein RB, Graham T, Thomas ED. Clinical and hematologic effects of cross circulation in baboons. Transfusion. 1969;9:23–31.CrossRefPubMedGoogle Scholar
  47. 47.
    Bensinger WI, Clift R, Martin P, et al. Allogeneic peripheral blood stem cell transplantation in patients with advanced hematologic malignancies: a retrospective comparison with marrow transplantation. Blood. 1996;88:2794–2800.PubMedGoogle Scholar
  48. 48.
    Hansen JA, Clift RA, Thomas ED, Buckner CD, Storb R, Giblett ER. Transplantation of marrow from an unrelated donor to a patient with acute leukemia. N Engl J Med. 1980;303:565–567.CrossRefPubMedGoogle Scholar
  49. 49.
    Broxmeyer HE, Douglas GW, Hangoc G, et al. Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Proc Natl Acad Sci U S A. 1989;86:3828–3832.CrossRefPubMedPubMedCentralGoogle Scholar
  50. 50.
    Gluckman E, Broxmeyer HE, Auerbach AD, et al. Hematopoietic reconstitution in a patient with Fanconi’s anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med. 1989;321:1174–1178.CrossRefPubMedGoogle Scholar
  51. 51.
    Sandmaier BM, Storb R. Nonmyeloablative therapy and hematopoietic cell transplantation for hematologic disorders. In: Blume KG, Forman SJ, Appelbaum FR, eds. Thomas’ Hematopoietic Cell Transplantation. Oxford, UK: Blackwell Publishing Ltd; 2004:1164–1176.Google Scholar
  52. 52.
    Aversa F, Tabilio A, Terenzi A, et al. Successful engraftment of T-cell-depleted haploidentical “three-loci” incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum. Blood. 1994;84:3948–3955.PubMedGoogle Scholar
  53. 53.
    Ikehara S, Good RA, Nakamura T, et al. Rationale for bone marrow transplantation in the treatment of autoimmune diseases. Proc Natl Acad Sci U S A. 1985;82:2483–2487.CrossRefPubMedPubMedCentralGoogle Scholar
  54. 54.
    Kalb C, Rosenberg D. Stem cell division. Newsweek. 2004;144:42–50.PubMedGoogle Scholar

Copyright information

© The Japanese Society of Hematology 2005

Authors and Affiliations

  • E. Donnall Thomas
    • 1
  1. 1.Clinical DivisionFred Hutchinson Cancer Research CenterSeattleUSA

Personalised recommendations