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CC Chemokine Receptor 4-Positive Diffuse Large B-Cell Lymphoma Involving the Skin: A Case Report

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Abstract

Leukocyte trafficking is critically regulated by chemokines and their receptors. The involvement of the skin in certain subsets of T-cell malignancies has been explained by the discovery of an interaction between the thymus and activation-regulated chemokine (TARC), which is abundant in the skin, and its receptor, CC chemokine receptor 4 (CCR4), which is expressed in the tumor cells. We describe a diffuse large B-cell lymphoma (DLBCL) that showed CCR4 expression with involvement of the skin. A 55-year-old man presented with a giant skin ulcer of the right axilla, and his disease was diagnosed as DLBCL. Further clinical examination revealed an ulcerated gastric lymphoma lesion. Immunohistochemical and real-time reverse transcriptase-polymerase chain reaction analyses showed that the tumor cells were positive for CCR4, andTARC was expressed at extremely high levels in the lymphoma-affected skin. These observations suggest that the interaction between CCR4 and TARC played a significant role in the involvement of the skin in this case, similar to what has been observed in certain subsets of T-cell malignancies. To the best of our knowledge, this report is the first of a CCR4-positive B-cell lymphoma. The present case provides new insights into the pathogenesis of skin involvement in B-cell lymphomas.

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Authors and Affiliations

  1. Departments of Internal Medicine & Molecular Science, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho-chou, Mizuho-ku, Nagoya, 467-8601, Aichi, Japan

    Takashi Ishida, Atsushi Inagaki, Hirokazu Komatsu, Shinsuke Iida & Ryuzo Uedaa

  2. Departments ofPathology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan

    Hiroshi Inagaki

  3. Department of Hematology, Shizuoka Saiseikai General Hospital, Shizuoka, Japan

    Takashi Ishida, Shigeru Kusumoto, Shinsuke Harada & Genji Takeuchi

Authors
  1. Takashi Ishida
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  2. Hiroshi Inagaki
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  3. Shigeru Kusumoto
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  4. Atsushi Inagaki
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  5. Hirokazu Komatsu
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  6. Shinsuke Iida
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  7. Shinsuke Harada
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  8. Genji Takeuchi
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  9. Ryuzo Uedaa
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Corresponding author

Correspondence to Takashi Ishida.

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Ishida, T., Inagaki, H., Kusumoto, S. et al. CC Chemokine Receptor 4-Positive Diffuse Large B-Cell Lymphoma Involving the Skin: A Case Report. Int J Hematol 82, 148–151 (2005). https://doi.org/10.1532/IJH97.04154

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  • DOI: https://doi.org/10.1532/IJH97.04154

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