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International Journal of Hematology

, Volume 82, Issue 2, pp 148–151 | Cite as

CC Chemokine Receptor 4-Positive Diffuse Large B-Cell Lymphoma Involving the Skin: A Case Report

  • Takashi Ishida
  • Hiroshi Inagaki
  • Shigeru Kusumoto
  • Atsushi Inagaki
  • Hirokazu Komatsu
  • Shinsuke Iida
  • Shinsuke Harada
  • Genji Takeuchi
  • Ryuzo Uedaa
Case Report

Abstract

Leukocyte trafficking is critically regulated by chemokines and their receptors. The involvement of the skin in certain subsets of T-cell malignancies has been explained by the discovery of an interaction between the thymus and activation-regulated chemokine (TARC), which is abundant in the skin, and its receptor, CC chemokine receptor 4 (CCR4), which is expressed in the tumor cells. We describe a diffuse large B-cell lymphoma (DLBCL) that showed CCR4 expression with involvement of the skin. A 55-year-old man presented with a giant skin ulcer of the right axilla, and his disease was diagnosed as DLBCL. Further clinical examination revealed an ulcerated gastric lymphoma lesion. Immunohistochemical and real-time reverse transcriptase-polymerase chain reaction analyses showed that the tumor cells were positive for CCR4, andTARC was expressed at extremely high levels in the lymphoma-affected skin. These observations suggest that the interaction between CCR4 and TARC played a significant role in the involvement of the skin in this case, similar to what has been observed in certain subsets of T-cell malignancies. To the best of our knowledge, this report is the first of a CCR4-positive B-cell lymphoma. The present case provides new insights into the pathogenesis of skin involvement in B-cell lymphomas.

Key words

CCR4 TARC Diffuse large B-cell lymphoma 

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Copyright information

© The Japanese Society of Hematology 2005

Authors and Affiliations

  • Takashi Ishida
    • 1
    • 3
  • Hiroshi Inagaki
    • 2
  • Shigeru Kusumoto
    • 3
  • Atsushi Inagaki
    • 1
  • Hirokazu Komatsu
    • 1
  • Shinsuke Iida
    • 1
  • Shinsuke Harada
    • 3
  • Genji Takeuchi
    • 3
  • Ryuzo Uedaa
    • 1
  1. 1.Departments of Internal Medicine & Molecular ScienceNagoya City University Graduate School of Medical SciencesAichiJapan
  2. 2.Departments ofPathologyNagoya City University Graduate School of Medical SciencesNagoyaJapan
  3. 3.Department of HematologyShizuoka Saiseikai General HospitalShizuokaJapan

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