Abstract
A 28-year-old woman underwent renal transplantation in 1993. Eight years later, she experienced macroscopic hematuria, and Epstein-Barr virus-negative solitary extramedullary plasmacytoma (EMP) of the urinary bladder was diagnosed. After the reduction of immunosuppressive therapy, she received combined chemotherapy, resulting in complete tumor disappearance. However, 10 months later, she relapsed with aggressive multiple EMP and died of disease progression in 2003. This report is the first of a case of solitary EMP of the urinary bladder appearing as posttransplantation plasma cell dyscrasias after renal transplantation.
Similar content being viewed by others
References
Nalesnik MA, Jaffe R, Starzl TE, et al. The pathology of posttransplant lymphoproliferative disorders occurring in the setting of cyclosporine A-prednisone immunosuppression. Am J Pathol. 1988;133:173–192.
Curtis RE, Travis LB, Rowlings PA, et al. Risk of lymphoproliferative disorders after bonemarrow transplantation: a multi-institutional study. Blood. 1999;94;2208–2216.
Caillard S, Lachat V, Moulin B, PTLD French Working Group. Posttransplant lymphoproliferative disorders in renal allograft recipients: report of 53 cases of a French multicenter study. Transpl Int. 2000;13:S388-S393.
Joseph G, Barker RL, Yuan B, Martin A, Medeiros J, Peiper SC. Posttransplantation plasma cell dyscrasias. Cancer. 1994;74:1959–1964.
Hara H, Yamane T, Yamashita K. Extramedullary plasmacytoma of the gastro-intestinal tract in a renal transplant recipient. Acta Pathol Jpn. 1979;29:661–668.
Melato M, Paladini G. Multiple myeloma following reactivated Epstein-Barr virus infection in a renal transplant recipient. Hematologica. 1986;71:241–243.
Birkeland SA, Hamilton-Dutoit. Is posttransplant lymphoproliferative disorder (PTLD) caused by any specific immunosuppressive drug or by the transplantation pre se? Transplantation. 2003;76:984–988.
Lopez A, Mendez F, Puras-Baez A. Extramedullary plasmacytoma invading the bladder: case report and review of the literature. Urol Oncol. 2003;21:419–423.
Matsumiya K, Ueyama Y, Kanayama Y, Iwasaki M, Yamaguchi S, Osafune M. Extramedullary plasmacytoma (EMP) of urinary bladder. Urology. 1992;40:67–70.
Yang C, Sandeman TF. Extramedullary plasmacytoma of the bladder: a case report and review of literature. Cancer. 1982;50:146–149.
Ozan O, Guler M. Extramedullary plasmacytoma of the bladder. Acta Urol. 1986;54:431–433.
Swinnen LJ. Diagnosis and treatment of transplant-related lymphoma. Ann Oncol. 2000;11:S45-S48.
Armitage JM, Kormos RL, Stuart RS, et al. Posttransplant lymphoprolifeartive disease in thoracic organ transplant patients: ten years of cyclosporine-based immunosuppression. J Heart Lung Transplant. 1991;10:877–887.
Au WY, Lie AK, Chan EC, et al. Treatment of postrenal transplantation lymphoproliferative disease manifesting as plasmacytoma with nonmyeloablative hematopoietic stem cell transplantation from the same kidney donor. Am J Hematol. 2003;47:283–286.
Leblond V, Davi F, Charlotte F, et al. Posttransplant lymphoproliferative disorders not associated with Epstein-Barr virus: a distinct entity? J Clin Oncol. 1998;16:2052–2059.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Takahashi, R., Nakano, S., Namura, K. et al. Plasmacytoma of the Urinary Bladder in a Renal Transplant Recipient. Int J Hematol 81, 255–257 (2005). https://doi.org/10.1532/IJH97.04148
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1532/IJH97.04148