International Journal of Hematology

, Volume 80, Issue 5, pp 463–466 | Cite as

Experience with the Use of Salazosulfapyridine for Intractable Diarrhea after Hematopoietic Stem Cell Transplantation

  • Naohiko Moriguchi
  • Sadayuki Isokawa
  • Atsushi Ando
  • Hiroshi Miyata
Case Report


We encountered 2 children with intractable diarrhea after allogeneic hematopoietic stem cell transplantation (SCT). In both cases, salazosulfapyridine (SASP) was administered to treat the diarrhea. One patient was a 14-year-old male with acute mye-logenous leukemia who received SCT from a related HLA-identical donor. The leukemia recurred early, and a second SCT from the same donor was performed approximately half a year later. Because intestinal graft-versus-host disease (GVHD) was observed, steroids and octreotide were administered, but the symptoms were not improved. Thereafter, SASP was administered, and the symptoms remitted 9 days later. The other patient was a 12-year-old male with chronic myelogenous leukemia who received SCT from an unrelated HLA-identical donor. Diarrhea and abdominal pain developed early after engraftment and did not respond to either steroids or tacrolimus. Oral administration of SASP was initiated on day 236, and the diarrhea remitted 4 days later without recurrence thereafter. SASP may be effective in children for the digestive system symptoms of chronic GVHD.

Key words

Stem cell transplantation Diarrhea Graft-versus-host disease Salazosulfapyridine 


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Copyright information

© The Japanese Society of Hematology 2004

Authors and Affiliations

  • Naohiko Moriguchi
    • 1
  • Sadayuki Isokawa
    • 2
  • Atsushi Ando
    • 1
  • Hiroshi Miyata
    • 1
  1. 1.Department of PediatricsSakai Hospital, Kinki University School of MedicineSakai
  2. 2.Department of PediatricsKinki University School of MedicineOsakaJapan

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