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International Journal of Hematology

, Volume 80, Issue 3, pp 287–290 | Cite as

Successful Unrelated Cord Blood Transplantation Using a Reduced-Intensity Conditioning Regimen in a 6-Month-Old Infant with Congenital Neutropenia Complicated by Severe Pneumonia

  • Yozo Nakazawa
  • Kazuo Sakashita
  • Mizuho Kinoshita
  • Ken Saida
  • Tomonari Shigemura
  • Ryu Yanagisawa
  • Takehiko Kamijo
  • Naoto Shikama
  • Kenichi Koike
Case Report

Abstract

Here we report the first successful unrelated cord blood transplantation (CBT) using reduced-intensity conditioning for the treatment of congenital neutropenia in a 6-month-old infant with complications of severe pneumonia probably due to Staphylococcus aureus infection. Because the patient showed no response to treatment with granulocyte colony-stimulating factor and had a cytogenetic aberration, unrelated CBT with an HLA-DRB1 genotypic mismatch was performed. The number of infused cells was 15x107/kg.The preparative regimen was fludarabine, cyclophosphamide, and 6 Gy of total body irradiation. Teicoplanin was administered for bacterial pneumonia. Neutrophil engraftment was achieved on day 41 and was followed by clinical improvement. The patient gradually caught up on growth and development after the CBT. Unrelated CBT using a reduced-intensity conditioning regimen may be an effective treatment for congenital neutropenia.

Key words

Kostmann syndrome Cord blood transplantation Reduced-intensity stem cell transplantation Total body irradiation 

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Copyright information

© The Japanese Society of Hematology 2004

Authors and Affiliations

  • Yozo Nakazawa
    • 1
  • Kazuo Sakashita
    • 1
  • Mizuho Kinoshita
    • 1
  • Ken Saida
    • 1
  • Tomonari Shigemura
    • 1
  • Ryu Yanagisawa
    • 1
  • Takehiko Kamijo
    • 1
  • Naoto Shikama
    • 2
  • Kenichi Koike
    • 1
    • 3
  1. 1.Department of PediatricsShinshu University School of MedicineAsahi, MatsumotoJapan
  2. 2.Department of RadiologyJapan
  3. 3.Institute of Organ Transplants Reconstructive Medicine and Tissue EngineeringShinshu University School of MedicineMatsumotoJapan

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