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International Journal of Hematology

, Volume 80, Issue 3, pp 278–280 | Cite as

Aleukemic Leukemia Cutis in a Patient with Philadelphia Chromosome-Positive Biphenotypic Leukemia

  • Masahiro Onozawa
  • Satoshi Hashino
  • Hiroe Kanamori
  • Koh Izumiyama
  • Masakatsu Yonezumi
  • Koji Chiba
  • Takeshi Kondo
  • Takashi Fukuhara
  • Junji Tanaka
  • Masahiro Imamura
  • Masahiro Asaka
Case Report

Abstract

Aleukemic leukemia cutis is a rare condition characterized by the invasion of leukemic blasts into the skin before their appearance in the peripheral blood. Leukemia cutis usually occurs in patients with myeloid leukemia, especially the myelomonocytic and monocytic types of acute myeloblastic leukemia. We describe the case of a 62-year-old woman with aleukemic leukemia cutis who developed Philadelphia-positive acute leukemia 1 month after skin involvement. Leukemic cells expressed both myeloid and B-cell lineage surface markers, and monoclonal rearrangement of the immunoglobulin heavy chain was detected by Southern blot analysis. This report is the first of a case of aleukemic leukemia cutis preceding Philadelphia-positive biphenotypic leukemia.

Key words

Aleukemic leukemia cutis Philadelphia chromosome Biphenotypic leukemia 

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Copyright information

© The Japanese Society of Hematology 2004

Authors and Affiliations

  • Masahiro Onozawa
    • 1
  • Satoshi Hashino
    • 1
  • Hiroe Kanamori
    • 1
  • Koh Izumiyama
    • 1
  • Masakatsu Yonezumi
    • 1
  • Koji Chiba
    • 1
  • Takeshi Kondo
    • 1
  • Takashi Fukuhara
    • 2
  • Junji Tanaka
    • 3
  • Masahiro Imamura
    • 3
  • Masahiro Asaka
    • 1
  1. 1.Department of Gastroenterology and HematologyHokkaido University Graduate School of MedicineSapporoJapan
  2. 2.Department of Internal MedicineAsahikawa City HospitalAsahikawaJapan
  3. 3.Departments of Hematology and OncologyHokkaido University Graduate School of MedicineSapporo

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