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International Journal of Hematology

, Volume 80, Issue 2, pp 183–185 | Cite as

Primary Myelofibrosis Terminated in Basophilic Leukemia and Successful Allogeneic Bone Marrow Transplantation

  • Naoshi Sugimoto
  • Takayuki Ishikawa
  • Saori Gotoh
  • Isaku Shinzato
  • Akiko Matsushita
  • Kenichi Nagai
  • Noriko Ohgoh
  • Takayuki Takahashi
Case Report

Abstract

Transformation of primary myelofibrosis (PMF) to basophilic leukemia is very rare.We report the case of a 44-year-old man who had had PMF for 6 years. His hematopoiesis deteriorated with marked splenomegaly, requiring multiple red blood cell and platelet transfusions. Soon after splenectomy, progressive basophilia (32.3x109/L) developed, infiltrating the skin as well as the bone marrow.The patient underwent allogeneic bone marrow transplantation with cells from an HLA-matched sibling. Despite the presence of hyperhistaminemia (99.1 ng/mL) after conditioning with cyclophosphamide, the pregrafting and postgrafting periods were uneventful. Prophylactic administration of both H1 and H2 receptor antagonists and sufficient hydration appeared to be important.

Key words

Primary myelofibrosis Basophilic leukemia Allogeneic bone marrow transplantation Hyperhistaminemia 

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Copyright information

© The Japanese Society of Hematology 2004

Authors and Affiliations

  • Naoshi Sugimoto
    • 1
    • 3
  • Takayuki Ishikawa
    • 1
    • 3
  • Saori Gotoh
    • 1
  • Isaku Shinzato
    • 1
  • Akiko Matsushita
    • 1
  • Kenichi Nagai
    • 1
  • Noriko Ohgoh
    • 2
  • Takayuki Takahashi
    • 1
  1. 1.Department of Hematology and Clinical ImmunologyKobe City General HospitalChuo-kuJapan
  2. 2.Departments of DermatologyKobe City General HospitalKobeJapan
  3. 3.Department of Hematology and OncologyGraduate School of Medicine, Kyoto UniversityJapan

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