International Journal of Hematology

, Volume 79, Issue 5, pp 474–479 | Cite as

Case of B-Cell Lymphoma with Rearrangement of the BCL1, BCL2, BCL6, and c-MYC Genes

  • Keiki Kawakami
  • Setsuko Miyanishi
  • Takashi Sonoki
  • Shigeo Nakamura
  • Kenichi Nomura
  • Masafumi Taniwaki
  • Tetsuya Murata
  • Shigenori Kadowaki
  • Norimitsu Kadowaki
  • Ikuo Miura
Case Report


We managed a peculiar case of lymphoma showing immunohistochemical overexpression of cyclin D1. At initial examination the patient had meningeal lymphomatosis and general lymphadenopathy. Histologic examination of biopsy specimens of inguinal lymph nodes showed tumor cells and vague nodular growth resembling lymphoblasts. The results of flow cytometric analysis were positive for CD10, CD20, CD103, and immunoglobulin G (IgG) and Igκ and were negative for CD5, CD23, and terminal deoxynucleotidyl transferase activity. Results of immunohistochemical analysis of paraffin-embedded specimens were positive for cyclin D1 and Bc12 in the tumor cells. Sixty percent of tumor cells had positive results for MIB1/Ki67. Cytogenetic and molecular studies revealed tumor cells simultaneously had t(14;18)(q32;q21), t(11;22)(q13;q11), t(8;14)(q24;q32), and t(3;14)(q27;q32) with the rearrangement of BCL1, BCL2, BCL6, and c-MYC genes. Lymphadenopathy showed a quick and complete response to doxorubicin-containing systemic chemotherapy with rituximab, but the central nervous system disease progressed and killed the patient.

Key words

Malignant lymphoma BCL1 BCL2 BCL6 c-MYC 


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Copyright information

© The Japanese Society of Hematology 2004

Authors and Affiliations

  • Keiki Kawakami
    • 1
  • Setsuko Miyanishi
    • 2
  • Takashi Sonoki
    • 3
  • Shigeo Nakamura
    • 4
  • Kenichi Nomura
    • 5
  • Masafumi Taniwaki
    • 6
  • Tetsuya Murata
    • 7
  • Shigenori Kadowaki
    • 1
  • Norimitsu Kadowaki
    • 8
  • Ikuo Miura
    • 9
  1. 1.Division of HematologySuzuka General HospitalSuzuka, MieJapan
  2. 2.Division of Medical ReseachTenri HospitalNara
  3. 3.Internal Medicine IIKumamoto University School of MedicineKumamoto
  4. 4.Department of Pathology and Clinical LaboratoriesAichi Cancer Center HospitalNagoya
  5. 5.Molecular Hematology and OncologyGraduate School of Medicine, Kyoto Prefectural University of MedicineKyoto
  6. 6.Clinical Molecular Genetics and Laboratory MedicineGraduate School of Medicine, Kyoto Prefectural University of MedicineKyoto
  7. 7.Divison of Pathology and Clinical LaboratoriesSuzuka General HospitalSuzuka
  8. 8.Department of Hematology and Oncology Graduate School of MedicineKyoto UniversityKyoto
  9. 9.Third Department of Internal MedicineAkita University School of MedicineAkitaJapan

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