Case of B-Cell Lymphoma with Rearrangement of the BCL1, BCL2, BCL6, and c-MYC Genes
- 64 Downloads
We managed a peculiar case of lymphoma showing immunohistochemical overexpression of cyclin D1. At initial examination the patient had meningeal lymphomatosis and general lymphadenopathy. Histologic examination of biopsy specimens of inguinal lymph nodes showed tumor cells and vague nodular growth resembling lymphoblasts. The results of flow cytometric analysis were positive for CD10, CD20, CD103, and immunoglobulin G (IgG) and Igκ and were negative for CD5, CD23, and terminal deoxynucleotidyl transferase activity. Results of immunohistochemical analysis of paraffin-embedded specimens were positive for cyclin D1 and Bc12 in the tumor cells. Sixty percent of tumor cells had positive results for MIB1/Ki67. Cytogenetic and molecular studies revealed tumor cells simultaneously had t(14;18)(q32;q21), t(11;22)(q13;q11), t(8;14)(q24;q32), and t(3;14)(q27;q32) with the rearrangement of BCL1, BCL2, BCL6, and c-MYC genes. Lymphadenopathy showed a quick and complete response to doxorubicin-containing systemic chemotherapy with rituximab, but the central nervous system disease progressed and killed the patient.
Key wordsMalignant lymphoma BCL1 BCL2 BCL6 c-MYC
Unable to display preview. Download preview PDF.
- 4.Swerdlow SH, Berger F, Issacson PI, et al. Mantle cell lymphoma. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. Pathology and Genetics: Tumors of Haematopoietic and Lymphoid Tissues— World Health Organization Classification of Tumors. Lyon, France:IARC Press; 2001:168–170.Google Scholar
- 10.Nomura K, Yoshino T, Nakamura S, et al. Detection of t(11;18) (q21;q21) in marginal zone lymphoma of mucosa-associated lymphocytic tissue type on paraffin-embedded tissue sections by using fluorescence in situ hybridization. Cancer Genet Cytogenet. 2003;140:49–54.CrossRefPubMedPubMedCentralGoogle Scholar
- 15.Sonoki T, Siebert R, Taniguchi I, Hata H, Dyer MJS, Mitsuya H. Activation of MYC by cytogenetically cryptic chromosome translocation, t(8;17)(q24;q22). Ann Oncol. 2002;13(suppl 2):50.Google Scholar