Skip to main content
SpringerLink
Log in

Membranous nephropathy after allogeneic stem cell transplantation: meport of 2 cases

  • Published:
International Journal of Hematology Aims and scope Submit manuscript

Abstract

Nephrotic syndrome (NS) is a rare complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). The cases of 2 patients who developed NS after receiving allo-IISCT for chronic myelogenous leukemia and acute lymphoblastic leukemia arc described. In both cases, renal biopsy revealed membranous nephropathy (MN), and the patients achieved remission after treatment with prednisolone. Previously reported cases and our experience suggest that most NS patients show MN in histologic tests after allo-HSCT and that its development is related to graft-versus-host disease. Rarly treatment with steroids seems effective for resolving symptoms of NS and improving renal function.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Kist-van Holthe JE, van Zwet JM, Brand R, van Weel MH, Vossen JM, van der Heijden AJ. Bone marrow transplantation in children: consequences for renal function shortly after and 1 year post-BMT.Bone Marrow Transplant. 1998;22:55)-564.

    Google Scholar 

  2. Thomas F.D, Storb R, Clift RA, et al. Bone-marrow transplantation.N Engl J Med. 1975;292:832–843,895-902.

    Article  CAS  PubMed  Google Scholar 

  3. Ferrara JL, Deeg HJ. Graft-versus-host disease.N Engl J Med. 1991 ;324:667–674.

    Article  CAS  PubMed  Google Scholar 

  4. Lin J, Markowitz GS, Nicolaides M, et al. Membranous glomeru- lopathy associated with graft-versus-host disease following allogeneic stem cell transplantation: report of 2 cases and review of the literature.Am J Nephrol. 2001;21:351–356.

    Article  CAS  PubMed  Google Scholar 

  5. Imai H, Oyama Y, Miura AB, Endoh M, Sakai H. Hematopoietic cell transplantation-related nephropathy in Japan.Am J Kidney Dis. 2000: 36:474–480.

    Article  CAS  PubMed  Google Scholar 

  6. Bruijn JA, Van Elven EH, Corver WE, Oudshoom-Snoek M, Fleuren GJ. Genetics of experimental lupus nephritis: non-H-2 factors determine susceptibility for renal involvement in raurine chronic graft-versus-host disease.Clin Exp Immunol. 1989;76:284–289.

    CAS  PubMed Central  PubMed  Google Scholar 

  7. Gleichmann E, Van Elven EH, Van der Veen JP. A systemic lupus erythematosus (SLE)-like disease in mice induced by abnormal T-B cell cooperation: preferential formation of autoantibodies characteristic of SLE.Eur J Immunol. 1982;12:152–159.

    Article  CAS  PubMed  Google Scholar 

  8. Gomez-Garcia P, Herrera-Arroyo C, Torres-Gomez A, et al. Renal involvement in chronic graft-versus-host disease: a report of two cases.Bone Marrow Transplant. 1988;3:357–362.

    CAS  PubMed  Google Scholar 

  9. Hiesse C, Goldschmidt E, Santelli G, Charpentier B, Machover D, Fries D. Membranous nephropathy in a bone marrow transplant recipient.Am J Kidney Dis. 1988;11:188–191.

    CAS  PubMed  Google Scholar 

  10. Müller GA, Müller CA, Markovic-Lipkowski J, et al. Membranous nephropathy after bone marrow transplantation in ciclosporin treatment.Nephron. 1989;51:555–556.

    Article  PubMed  Google Scholar 

  11. Barbara JA, Thomas AC, Smith PS, Gillis D, Ho JO, Woodroffe AJ. Membranous nephropathy with graft-versus-host disease in a bone marrow transplant recipient.Clin Nephrol. 1992;37:115–118.

    CAS  PubMed  Google Scholar 

  12. Sato N, Kishi K, Yagisawa K, et al. Nephrotic syndrome in a bone marrow transplant recipient with chronic graft-versus-host disease.Bone Marrow Transplant. 1995;16:303–305.

    CAS  PubMed  Google Scholar 

  13. Walker JV, Morich D, Anasetti C. Minimal-change nephrotic syndrome after cyclosporine withdrawal in a marrow transplant recipient.Am J Kidney Dis. 1995;26:532–534.

    Article  CAS  PubMed  Google Scholar 

  14. Haseyama K,Watanabe J, Oda T, et al. Nephrotic syndrome related to chronic graft versus host disease after allogeneic bone marrow transplantation in a patient with malignant lymphoma [in Japanese].Rinsho Ketsueki. 1996;37:1383–1388.

    CAS  PubMed  Google Scholar 

  15. Yabana M, Takagi N, Kihara M, et al. A case of nephrotic syndrome after bone marrow transplantation [in Japanese].Nippon Jinzo Gakkai Shi. 1997;39:414–420.

    CAS  PubMed  Google Scholar 

  16. Yorioka N, Taniguchi Y, Shimote K, et al. Membranous nephropathy with chronic graft-versus-host disease in a bone marrow transplant recipient.Nephron. 1998;80:371–372.

    Article  CAS  PubMed  Google Scholar 

  17. Nergizoglu G, Keven K, Ates K, et al. Chronic graft-versus-host disease complicated by membranous glomerulonephritis.Nephrol Dial Transplant. 1999;14:2461–2463.

    Article  CAS  PubMed  Google Scholar 

  18. Oliveira JS, Bahia D, Franco M, Balda C, Stella S, Kerbauy J. Nephrotic syndrome as a clinical manifestation of graft-versus- host disease (GVHD) in a marrow transplant recipient after cyclosporine withdrawal.Bone Marrow Transplant. 1999;23:99–101.

    Article  CAS  PubMed  Google Scholar 

  19. Chien YH, Lin KH, Lee TY, Lu MY,Tsau YK. Nephrotic syndrome in a bone marrow transplant recipient without chronic graft-versus-host disease.J Formos Med Assoc. 2000;99:503–506.

    CAS  PubMed  Google Scholar 

  20. Ohsawa I, Ohi H, Fujita T, et al. Glomerular and extraglomerular immune complex deposits in a bone marrow transplant recipient.Am J Kidney Dis. 2000;36:E3.

    Article  CAS  PubMed  Google Scholar 

  21. Ishizuka Y, Yokota A, Hara S, et al. Transient nephrotic syndrome after allogeneic bone marrow transplantation for chronic myel- ogenous leukemia [in Japanese].Rinsho Ketsueki. 2001: 42:321–327.

    CAS  PubMed  Google Scholar 

  22. Rossi L, Cardarelli F, Vampa ML, Buzio C, Olivetti G. Membranous glomerulonephritis after haematopoietic cell transplantation for multiple myeloma.Nephron. 2001 ;88:260–263.

    Article  CAS  PubMed  Google Scholar 

  23. Akar H, Keven K, Celebi H, et al. Nephrotic syndrome after allogeneic peripheral blood stem cell transplantation.J Nephrol. 2002; 15:79–82.

    PubMed  Google Scholar 

  24. Suehiro T, Masutani K, Yokoyama M, et al. Diffuse proliferative glomerulonephritis after bone marrow transplantation.Clin Nephrol. 2002;58:231–237.

    Article  CAS  PubMed  Google Scholar 

  25. Kimura S, Horie A, Hiki Y, et al. Nephrotic syndrome with crescent formation and massive IgA deposition following allogeneic bone marrow transplantation for natural killer cell leukemia/lymphoma.Blood. 2003;101:4219–4221.

    Article  CAS  PubMed  Google Scholar 

  26. Sakarcan A, Neuberg RW, McRedmond KP, et al. Membranopro- liferative glomerulonephritis develops in a child with autologous stem cell transplant.Am J Kidney Dis. 2002;40:F19.

    Article  Google Scholar 

  27. Masuya M, Drake CJ, Fleming PA, et al. Hematopoietic origin of glomerular mesangial cells.Blood. 2003;101:2215–2218.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University Graduate School, of Biosciences, 1-12-4, Sakamoto, 852-8523, Nagasaki, Japan

    Chizuko Tsutsumi, Yasushi Miyazaki, Takuya Fukushima, Shinichiro Yoshida, Jun Taguchi, Ttsuro Jinnai & Masao Tomonaga

  2. Second Department of Internal Medicine, Nagasaki University Graduate School, of Biosciences, 1-12-4, Sakamoto, 852-8523, Nagasaki, Japan

    Chie Miyake, Masanobu Miyazaki & Shigeru Kohno

Authors
  1. Chizuko Tsutsumi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yasushi Miyazaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Takuya Fukushima
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shinichiro Yoshida
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jun Taguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Chie Miyake
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Masanobu Miyazaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Shigeru Kohno
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Ttsuro Jinnai
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Masao Tomonaga
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chizuko Tsutsumi.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tsutsumi, C., Miyazaki, Y., Fukushima, T. et al. Membranous nephropathy after allogeneic stem cell transplantation: meport of 2 cases. Int J Hematol 79, 193–197 (2004). https://doi.org/10.1532/IJH97.03096

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1532/IJH97.03096

Key words

Search

Navigation