International Journal of Hematology

, Volume 85, Issue 2, pp 149–153

Isolated extramedullary relapse in the breast of a patient with acute myeloid leukemia following allogeneic stem cell transplantation: case report and review of the literature

  • Abderrahman Abdelkefi
  • Lamia Torjman
  • Saloua Ladeb
  • Zeineb Sghaïer
  • Ramzi Jeddi
  • Amel Lakhal
  • Amr Ramzu
  • Amor Gamoudi
  • Tarek Ben Othman
Case report

DOI: 10.1532/IJH97.E0628

Cite this article as:
Abdelkefi, A., Torjman, L., Ladeb, S. et al. Int J Hematol (2007) 85: 149. doi:10.1532/IJH97.E0628

Abstract

We report an unusual case of a woman with acute myeloid leukemia who showed an isolated extramedullary relapse (IEMR) in the breast following allogeneic stem cell transplantation and review the related literature. Eighty cases of IEMR following allogeneic stem cell transplantation, including our case, were identified. The review suggests that an M2 or M4 phenotype in the French-American-British classification and a favorable cytogenetic risk group are more frequently associated with the occurrence of IEMR. Combined treatment with radiation and high-dose chemotherapy may be effective.

Key words

Granulocytic sarcoma Isolated extramedullary relapse Acute myeloid leukemia Breast Allogeneic transplantation 

Copyright information

© The Japanese Society of Hematology 2007

Authors and Affiliations

  • Abderrahman Abdelkefi
    • 1
  • Lamia Torjman
    • 1
  • Saloua Ladeb
    • 1
  • Zeineb Sghaïer
    • 1
  • Ramzi Jeddi
    • 2
  • Amel Lakhal
    • 1
  • Amr Ramzu
    • 1
  • Amor Gamoudi
    • 3
  • Tarek Ben Othman
    • 1
  1. 1.Centre National de Greffe de Moelle OsseuseRue Jebel LakhdarTunisTunisia
  2. 2.Hôpital Aziza OthmanaTunisTunisia
  3. 3.Institut Salah AzaizTunisTunisia

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