Combination Therapy with Thalidomide, Incadronate, and Dexamethasone for Relapsed or Refractory Multiple Myeloma

  • Naoya Ochiai
  • Noriko Yamada
  • Ryo Uchida
  • Shin-ichi Fuchida
  • Akira Okano
  • Mayumi Hatsuse
  • Masashi Okamoto
  • Eishi Ashihara
  • Chihiro Shimazaki


The feasibility and efficacy of a combination of thalidomide, incadronate, and dexamethasone (TID) were studied in 12 patients with relapsed or refractory multiple myeloma. The protocol, consisting of 300 mg/day of thalidomide administered orally, intravenous incadronate (10 mg/day) administered weekly, and 12 mg/day dexamethasone for 4 days, was repeated every 3 weeks. Evaluations of efficacy and toxicity were carried out every 3 weeks and were continued for 3 cycles. Three patients were excluded during the study because of apnea, severe somnolence, and pancytopenia. Of 9 evaluated patients, the partial responses achieved in 3 patients and the minor responses achieved in 4 patients corresponded to a response rate of 78% according to the criteria of the European Group for Blood and Marrow Transplantation. In addition, painful osteolytic symptoms improved rapidly after 1 cycle of TID therapy in the 10 patients evaluated. These data suggest that TID is a feasible and promising therapeutic approach for refractory and relapsed multiple myeloma.

Key words

Multiple myeloma Thalidomide Incadronate Dexamethasone 


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Copyright information

© The Japanese Society of Hematology 2005

Authors and Affiliations

  • Naoya Ochiai
    • 1
  • Noriko Yamada
    • 1
  • Ryo Uchida
    • 1
  • Shin-ichi Fuchida
    • 1
  • Akira Okano
    • 1
  • Mayumi Hatsuse
    • 2
  • Masashi Okamoto
    • 1
  • Eishi Ashihara
    • 1
  • Chihiro Shimazaki
    • 1
  1. 1.Division of Hematology and Oncology, Department of MedicineKyoto Prefectural University of MedicineKyotoJapan
  2. 2.Shakaihoken Kyoto HospitalKyotoJapan

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