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International Journal of Hematology

, Volume 81, Issue 4, pp 294–300 | Cite as

Epigenetic Regulation of Hematopoietic Stem Cell Self-Renewal by Polycomb Group Genes

  • Atsushi IwamaEmail author
  • Hideyuki Oguro
  • Masamitsu Negishi
  • Yuko Kato
  • Hiromitsu NakauchiEmail author
Progress in Hematology

Abstract

Polycomb group (PcG) genes are involved in the maintenance of cellular memory through epigenetic chromatin modifications. Recent studies have implicated a role for PcG genes in the self-renewal of hematopoietic stem cells (HSCs), a process in which cellular memory is maintained through cell division. Among the PcG genes, Bmi-1 plays a central role in the inheritance of stemness, and its forced expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation.

Key words

Polycomb group genes Hematopoietic stem cells Bmi-1 Cellular memory Epigenetic regulation Self-renewal 

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Copyright information

© The Japanese Society of Hematology 2005

Authors and Affiliations

  1. 1.Laboratory of Stem Cell Therapy, Center for Experimental Medicine, The Institute of Medical ScienceUniversity of TokyoTokyoJapan
  2. 2.Department of Cellular and Molecular Biology, Graduate School of MedicineChiba UniversityChibaJapan

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