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Figure 4 | The EMBO Journal

Figure 4

From: Regulation of RNA polymerase II processivity by Spt5 is restricted to a narrow window during elongation

Figure 4The alternative text for this image may have been generated using AI.

Spt5 depletion leads to delayed transcription termination

A. Representative UCSC genome browser snapshots of two genes showing increased Pol II, Ser2P‐Pol II, and GROseq signal in the region beyond the transcription termination site (TTS). WT and Spt5dep tracks are overlaid in blue and red representing WT and Spt5dep signal, respectively, and black representing the overlap between them. The boxed area highlights the region (termination zone) where Pol II occupancy and nascent transcription extend further downstream in Spt5dep cells relative to WT cells.

B. Composite metagene plots of GROseq, Pol II, and Ser2P‐Pol II density −10 kb to +40 kb from the TTS for all expressed genes > 50 kb (n = 1,739) in WT and Spt5dep MEFs. The arrows point to the region within the termination zone where Spt5 depletion leads to the extension of the termination zone.

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