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Preparation and properties of gelatin films incorporated with N-hydroxysuccinimide-activated end-bit binary acid

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Abstract

A series of novel cross-linkers, N-hydroxysuccinimide (NHS)-activated end-bit binary acid (NHS-C4, C5, C6, C8, C10, C14), were synthesised to modify gelatin films and the crosslinking effects were compared. Homogeneous films with the exception of the film crosslinked by NHS-C14 were observed and the thickness was measured using a scanning electron microscope. The section feature influenced by different film-treatment conditions was also recorded. The differential scanning calorimetry results indicated higher thermal stability. The water contact angles confirmed enhanced hydrophobicity. NHS-C6, which was used as a probe crosslinker, exhibited the best crosslinking effect that the content of the free -NH2 achieved was the lowest out of all the crosslinkers. The biodegradation results of gelatin films modified by NHS-C6 exhibited better degradation-resistance and excellent stability. In addition, the optimal experimental conditions were 45°C for 12 h when [NHS-C6]/[-NH2] = 2.5.

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Authors and Affiliations

  1. Shandong Provincial Key Laboratory of Fine Chemicals, Qilu University of Technology, Jinan, 250353, China

    Chen Zhuang, Fu-Rong Tao & Yue-Zhi Cui

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  1. Chen Zhuang
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  2. Fu-Rong Tao
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Correspondence to Fu-Rong Tao.

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Zhuang, C., Tao, FR. & Cui, YZ. Preparation and properties of gelatin films incorporated with N-hydroxysuccinimide-activated end-bit binary acid. Chem. Pap. 70, 505–514 (2016). https://doi.org/10.1515/chempap-2015-0226

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