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Eco-friendly conjugate hydrocyanation of α-cyanoacrylates using potassium hexacyanoferrate(II) as cyanating reagent

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Abstract

The conjugate hydrocyanation of α-cyanoacrylates through chemoselective 1,4-addition to synthesise α,β-dicyanopropanoates by one-pot two-step procedure using potassium hexacyanoferrate(II) as an eco-friendly cyanide source, benzoyl chloride as a promoter and potassium carbonate as a catalyst is described. The advantages of this protocol are use of a non-toxic, non-volatile and inexpensive cyanating reagent, high product yields and simple working procedure.

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu, 730070, China

    Yu-Peng Zhang & Zheng Li

  2. Editorial Department of the University Journal, Northwest Normal University, Lanzhou, Gansu, 730070, China

    Xiao-Chun Hu

Authors
  1. Yu-Peng Zhang
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  2. Xiao-Chun Hu
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  3. Zheng Li
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Correspondence to Zheng Li.

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Zhang, YP., Hu, XC. & Li, Z. Eco-friendly conjugate hydrocyanation of α-cyanoacrylates using potassium hexacyanoferrate(II) as cyanating reagent. Chem. Pap. 69, 596–603 (2015). https://doi.org/10.1515/chempap-2015-0055

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  • DOI: https://doi.org/10.1515/chempap-2015-0055

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